Neurological complications of Kaposi's sarcomat. An analysis of 5 cases and a review of the literature.

Important note: Information in this article was accurate in 1984. The state of the art may have changed since the publication date.

Neurological complications of Kaposi's sarcomat. An analysis of 5 cases and a review of the literature.

J Neurooncol. 1983;1(4):333-46. Unique Identifier : AIDSLINE MED/84291557
Barton NW; Safai B; Nielsen SL; Posner JB

Abstract: We analyzed the neurological complications in 25 patients with Kaposi's sarcoma, 5 encountered at Memorial Sloan-Kettering Cancer Center and 20 culled from the literature. Patients with all clinical forms of Kaposi's sarcoma [14 classical cases, 2 African cases, 5 cases associated with immunosuppressive therapy and 4 cases associated with acquired immunodeficiency syndrome (AIDS)] suffered neurological dysfunction which included neoplastic involvement of the nervous system (Kaposi's sarcoma or another primary), autoimmune disorders and opportunistic infections. Neoplastic involvement was recorded most frequently in patients with classical and African Kaposi's sarcoma and was favored in a setting of extensive tumor dissemination. Opportunistic infections (cryptococcal meningitis and cerebral toxoplasmosis) were observed in all forms of Kaposi's sarcoma but were most frequent in AIDS cases and correlated with the degree of immune dysfunction. Our data suggest that more diverse opportunistic central nervous system infections, neurological disorders of an autoimmune nature, and neoplastic involvement of the nervous system are to be anticipated in AIDS.

Keywords: Adult Aged Astrocytoma Brain Neoplasms/SECONDARY Candidiasis/COMPLICATIONS Cryptococcosis/COMPLICATIONS Encephalitis/COMPLICATIONS Female Hodgkin's Disease Human Lymphoma, Large-Cell Male Meningitis/COMPLICATIONS Middle Age Neoplasms, Multiple Primary Nervous System Diseases/*COMPLICATIONS Sarcoma, Kaposi's/*COMPLICATIONS/SECONDARY Skin Neoplasms/*COMPLICATIONS Toxoplasmosis/COMPLICATIONS JOURNAL ARTICLE

841230
M84C0057

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