A monoclonal antibody that defines p24, a core protein of adult T-cell leukemia virus, and its precursor. NLM AIDSLINE Important note: Information in this article was accurate in 1984. The state of the art may have changed since the publication date.

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A monoclonal antibody that defines p24, a core protein of adult T-cell leukemia virus, and its precursor.

Gann. 1984 Jul;75(7):595-602. Unique Identifier : AIDSLINE MED/84286573
Fujii M; Sugamura K; Hinuma Y

Abstract: A mouse hybridoma cell line, H15, produced monoclonal antibody reacting with all the adult T-cell leukemia (ATL) virus (ATLV)-bearing cell lines but none of the ATLV-negative cell lines tested. Binding of H15 antibody to ATLV-bearing cell surfaces was specifically blocked by anti-ATLV positive human sera. Radioimmunoprecipitation analyses revealed that the antigen detected by H15 antibody was p24, a core protein of ATLV. Pulse-chase experiments using H15 antibody led to the identification of a protein, p53, which could be a precursor of p24.
Keywords: Antibodies, Monoclonal/*IMMUNOLOGY Antibodies, Viral/IMMUNOLOGY Antigens, Viral/IMMUNOLOGY Cell Line HTLV-BLV Viruses/*IMMUNOLOGY Molecular Weight Protein Precursors/IMMUNOLOGY Support, Non-U.S. Gov't Viral Proteins/*IMMUNOLOGY JOURNAL ARTICLE

KWDantibodies,monoclonal/KWDimmunologyantibodies,viral/immunologyantigens,viral/immunologycelllinehtlv-blvviruses/KWDimmunologymolecularweightproteinprecursors/immunologysupport,non-uKWDsKWDgov'tviralproteins/KWDimmunologyjournalarticle
841230
M84C0038

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