Isolation of lymphocytopathic retroviruses from San Francisco patients with AIDS. NLM AIDSLINE Important note: Information in this article was accurate in 1984. The state of the art may have changed since the publication date.

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Isolation of lymphocytopathic retroviruses from San Francisco patients with AIDS.

Science. 1984 Aug 24;225(4664):840-2. Unique Identifier : AIDSLINE MED/84300260
Levy JA; Hoffman AD; Kramer SM; Landis JA; Shimabukuro JM; Oshiro LS

Abstract: Infectious retroviruses have been detected in 22 of 45 randomly selected patients with acquired immune deficiency syndrome (AIDS) and in other individuals from San Francisco. The AIDS-associated retroviruses (ARV) studied in detail had a type D morphology, Mg2+-dependent reverse transcriptase, and cytopathic effects on lymphocytes. The viruses can be propagated in an established adult human T cell line, HUT-78. They cross-react with antiserum to the lymphadenopathy-associated retrovirus isolated from AIDS patients in France. Antibodies to ARV were found in all 86 AIDS patients and in a high percentage of 88 other homosexual men in San Francisco. This observation indicates the widespread presence of these lymphocytopathic retroviruses and their close association with AIDS.
Keywords: Acquired Immunodeficiency Syndrome/IMMUNOLOGY/*MICROBIOLOGY Antibodies, Viral/ANALYSIS Bone Marrow/MICROBIOLOGY California Cell Line Cells, Cultured Cross Reactions Cytopathogenic Effect, Viral *Homosexuality Human HTLV-BLV Viruses/IMMUNOLOGY/*ISOLATION & PURIF/PHYSIOLOGY/ ULTRASTRUCTURE Leukocytes/MICROBIOLOGY Lymphatic Diseases/IMMUNOLOGY Male Reverse Transcriptase/METABOLISM Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. Syndrome T-Lymphocytes Virus Cultivation JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/immunology/KWDmicrobiologyantibodies,viral/analysisbonemarrow/microbiologycaliforniacelllinecells,culturedcrossreactionscytopathogeniceffect,viralKWDhomosexualityhumanhtlv-blvviruses/immunology/KWDisolation&purif/physiology/ultrastructureleukocytes/microbiologylymphaticdiseases/immunologymalereversetranscriptase/metabolismsupport,non-uKWDsKWDgov'tsupport,uKWDsKWDgov't,pKWDhKWDsKWDsyndromet-lymphocytesviruscultivationjournalarticle
841230
M84C0024

Copyright © 1984 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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