Homology of genome of AIDS-associated virus with genomes of human T-cell leukemia viruses. NLM AIDSLINE Important note: Information in this article was accurate in 1984. The state of the art may have changed since the publication date.

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Homology of genome of AIDS-associated virus with genomes of human T-cell leukemia viruses.

Science. 1984 Aug 31;225(4665):927-30. Unique Identifier : AIDSLINE MED/84300271
Arya SK; Gallo RC; Hahn BH; Shaw GM; Popovic M; Salahuddin SZ; Wong-Staal F

Abstract: A T lymphotropic virus found in patients with the acquired immune deficiency syndrome (AIDS) or lymphadenopathy syndrome has been postulated to be the cause of AIDS. Immunological analysis of this retrovirus and its biological properties suggest that it is a member of the family of human T-lymphotropic retroviruses known as HTLV. Accordingly, it has been named HTLV-III. In the present report it is shown by nucleic acid hybridization that sequences of the genome of HTLV-III are homologous to the structural genes (gag, pol, and env) of both HTLV-I and HTLV-II and to a potential coding region called pX located between the env gene and the long terminal repeating sequence that is unique to the HTLV family of retroviruses.
Keywords: Acquired Immunodeficiency Syndrome/*MICROBIOLOGY Base Sequence Cloning, Molecular Comparative Study DNA DNA, Viral Genes, Structural *Genes, Viral Human HTLV-BLV Viruses/CLASSIFICATION/*GENETICS *Nucleic Acid Hybridization Repetitive Sequences, Nucleic Acid RNA, Viral JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDmicrobiologybasesequencecloning,molecularcomparativestudydnadna,viralgenes,structuralKWDgenes,viralhumanhtlv-blvviruses/classification/KWDgeneticsKWDnucleicacidhybridizationrepetitivesequences,nucleicacidrna,viraljournalarticle
841230
M84C0023

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