Antigens encoded by the 3'-terminal region of human T-cell leukemia virus: evidence for a functional gene. NLM AIDSLINE Important note: Information in this article was accurate in 1984. The state of the art may have changed since the publication date.

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Antigens encoded by the 3'-terminal region of human T-cell leukemia virus: evidence for a functional gene.

Science. 1984 Oct 5;226(4670):57-61. Unique Identifier : AIDSLINE MED/84300343
Lee TH; Coligan JE; Sodroski JG; Haseltine WA; Salahuddin SZ; Wong-Staal F; Gallo RC; Essex M

Abstract: Antibodies in sera from patients with adult T-cell leukemia-lymphoma or from healthy carriers of type I human T-cell leukemia virus (HTLV) recognize an antigen of approximately 42 kilodaltons (p42) in cell lines infected with HTLV-I. Radiolabel sequence analysis of cyanogen bromide fragments of p42 led to the conclusion that this antigen is encoded in part by LOR, a conserved portion of the X region that is flanked by the envelope gene and the 3' long terminal repeat of HTLV-I. It is possible that this novel product mediates the unique transformation properties of the HTLV family.
Keywords: Amino Acid Sequence Antigens, Viral/*GENETICS Base Sequence Cell Line Cyanogen Bromide *Genes, Viral Human HTLV-BLV Viruses/*GENETICS/IMMUNOLOGY Peptide Fragments Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. Viral Proteins/*GENETICS JOURNAL ARTICLE

KWDaminoacidsequenceantigens,viral/KWDgeneticsbasesequencecelllinecyanogenbromideKWDgenes,viralhumanhtlv-blvviruses/KWDgenetics/immunologypeptidefragmentssupport,non-uKWDsKWDgov'tsupport,uKWDsKWDgov't,pKWDhKWDsKWDviralproteins/KWDgeneticsjournalarticle
841230
M84C0019

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