Identification of the putative transforming protein of the human T-cell leukemia viruses HTLV-I and HTLV-II. NLM AIDSLINE Important note: Information in this article was accurate in 1984. The state of the art may have changed since the publication date.

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Identification of the putative transforming protein of the human T-cell leukemia viruses HTLV-I and HTLV-II.

Science. 1984 Oct 5;226(4670):61-5. Unique Identifier : AIDSLINE MED/84300344
Slamon DJ; Shimotohno K; Cline MJ; Golde DW; Chen IS

Abstract: The human T-cell leukemia viruses HTLV-I and HTLV-II are unique among the transforming retroviruses of vertebrates in their ability to transform human T cells in vitro and in their close association with human malignancies (T-cell lymphomas and leukemia). Their genomes are relatively simple, containing the genes gag, pol, env, and a 3' region termed X. This 3' region may be responsible for the transforming potential of the viruses. The existence of proteins encoded by the 3' region has been postulated on the basis of multiple open reading frames. In the present study this region is shown to contain a gene encoding a protein of 40 kilodaltons in HTLV-I and 37 kilodaltons in HTLV-II. It is proposed that these proteins be called, respectively, p40xI and p37xII.
Keywords: Amino Acid Sequence B-Lymphocytes/MICROBIOLOGY Cell Line *Cell Transformation, Viral *Genes, Viral Human HTLV-BLV Viruses/ANALYSIS/*GENETICS/PHYSIOLOGY Immune Sera Molecular Weight Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. T-Lymphocytes/*MICROBIOLOGY Viral Proteins/GENETICS/IMMUNOLOGY/*PHYSIOLOGY JOURNAL ARTICLE

KWDaminoacidsequenceb-lymphocytes/microbiologycelllineKWDcelltransformation,viralKWDgenes,viralhumanhtlv-blvviruses/analysis/KWDgenetics/physiologyimmuneseramolecularweightsupport,non-uKWDsKWDgov'tsupport,uKWDsKWDgov't,pKWDhKWDsKWDt-lymphocytes/KWDmicrobiologyviralproteins/genetics/immunology/KWDphysiologyjournalarticle
841230
M84C0018

Copyright © 1984 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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