Abnormal B-cell proliferation associated with combined immunodeficiency, cytomegalovirus, and cultured thymus grafts. NLM AIDSLINE Important note: Information in this article was accurate in 1984. The state of the art may have changed since the publication date.

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Abnormal B-cell proliferation associated with combined immunodeficiency, cytomegalovirus, and cultured thymus grafts.

Am J Clin Pathol. 1984 Oct;82(4):487-90. Unique Identifier : AIDSLINE MED/84304034
Dictor M; Fasth A; Olling S

Abstract: A male infant in whom multiple recurrent multiorgan infections developed during the first six months of life was found to have combined immunodeficiency. Progressive pulmonary disease developed at age two years; cytomegalovirus (CMV) was isolated from the respiratory tract and urine. Three separate intramuscular grafts of cultured thymus fragments did not produce change in the course of the illness. Soon after age three years, IgG lambda appeared in the serum as an M-component. The patient died at age three and one-half years, with respiratory insufficiency due to pulmonary fibrosis. At autopsy, a malignant plasma cell infiltrate was limited to the retroperitoneum. The infiltrate replaced lymph node structures and surrounded nerve fascicles, which appeared necrotic, and contained CMV inclusions in ganglion cell nuclei. The plasma cells showed strong monoclonal staining for IgG lambda. Also noted was positive staining for J-chain, which has been reported previously in malignant plasma cells producing IgG. CMV could be responsible for abnormal B-cell proliferation in patients with defective immunoregulation who receive immunotherapy, as in lymphoid abnormalities associated with Epstein-Barr virus.
Keywords: B-Lymphocytes/*IMMUNOLOGY Case Report Cytomegalovirus/*ISOLATION & PURIF Histiocytes/CYTOLOGY Human Immunologic Deficiency Syndromes/*IMMUNOLOGY/PATHOLOGY Infant Kidney/PATHOLOGY Lung/PATHOLOGY Lymph Nodes/PATHOLOGY *Lymphocyte Transformation Male Organ Culture Spleen/CYTOLOGY/PATHOLOGY Thymus Gland/*TRANSPLANTATION JOURNAL ARTICLE

KWDb-lymphocytes/KWDimmunologycasereportcytomegalovirus/KWDisolation&purifhistiocytes/cytologyhumanimmunologicdeficiencysyndromes/KWDimmunology/pathologyinfantkidney/pathologylung/pathologylymphnodes/pathologyKWDlymphocytetransformationmaleorganculturespleen/cytology/pathologythymusgland/KWDtransplantationjournalarticle
841230
M84C0015

Copyright © 1984 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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