Follicular dendritic cells and virus-like particles in AIDS-related lymphadenopathy. NLM AIDSLINE Important note: Information in this article was accurate in 1984. The state of the art may have changed since the publication date.

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Follicular dendritic cells and virus-like particles in AIDS-related lymphadenopathy.

Lancet. 1984 Aug 18;2(8399):370-2. Unique Identifier : AIDSLINE MED/84294239
Armstrong JA; Horne R

Abstract: Follicular labyrinthine foci, consisting of an association of retrovirus-like particles with expanded dendritic reticular (antigen trapping) cells, are described in lymph nodes from four immunodeficient homosexual men with unexplained persistent lymphadenopathy. One patient has severe acquired immunodeficiency syndrome (AIDS) with complicating Pneumocystis carinii infection, and the others have AIDS-related lymphadenopathy syndrome. The findings support a role for routine electron microscopy as an aid to diagnostic evaluation of nodal tissue from patients with suspected AIDS. Viral non-lymphoid-cell tropism may be a significant factor in the pathogenesis of the disease.
Keywords: Acquired Immunodeficiency Syndrome/COMPLICATIONS/MICROBIOLOGY/ *PATHOLOGY Adult Human Lymph Nodes/MICROBIOLOGY/*ULTRASTRUCTURE Lymphatic Diseases/ETIOLOGY/MICROBIOLOGY/*PATHOLOGY Lymphocytes/ULTRASTRUCTURE Male Microscopy, Electron Middle Age Retroviridae/*ULTRASTRUCTURE JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/complications/microbiology/KWDpathologyadulthumanlymphnodes/microbiology/KWDultrastructurelymphaticdiseases/etiology/microbiology/KWDpathologylymphocytes/ultrastructuremalemicroscopy,electronmiddleageretroviridae/KWDultrastructurejournalarticle
841230
M84C0010

Copyright © 1984 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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