Kawaguchi A; Linde LM; Imachi T; Mizuno H; Akutsu H
To estimate the left atrial volume (LAV) and pulmonary blood flow in patients with congenital heart disease (CHD), we employed two-dimensional echocardiography (TDE). The LAV was measured in dimensions other than those obtained in conventional M-mode echocardiography (M-mode echo). Mathematical and geometrical models
Flow-cytometric DNA analyses of single cell nuclei were performed on nuclear suspensions prepared from biopsies of primary breast carcinomas in 638 patients. Propidium-iodide-stained cell nuclei were analysed in an Ortho 50-H Cytofluorograph. The patients were staged by the TMN classification. Sixty percent of all the
The medical records, premortem biopsy specimens, and autopsy materials from 36 patients with acquired immune deficiency syndrome (AIDS) were reviewed. The majority of the patients were homosexual men. Widely metastatic Kaposi s sarcoma was seen in eight patients, while tumor was confined to the skin in an additional t
Around 4000 cases of AIDS (acquired immunodeficiency syndrome) have been recorded worldwide. In Switzerland 18 cases has been reported to the Federal Office of Public Health up to February 1, 1984, of whom 15 were men and 3 women. Up to now 16 of the patients have died. 9 of t
Ann Intern Med. 1984 Oct;101(4):421-8. Unique Identifier : AIDSLINE MED/84305410
Kotler DP; Gaetz HP; Lange M; Klein EB; Holt PR
To explore the effect of the acquired immunodeficiency syndrome on gastrointestinal structure and absorption, the cases of 12 homosexual men with the syndrome and 11 homosexual controls were studied. Seven patients had diarrhea with weight loss. Bacterial or parasitic infections were not detected. All patients were ma
Between January 1982 and December 1983, 75 patients with the acquired immunodeficiency syndrome were identified in our hospitals: 35% used intravenous drugs, 50% had proteinuria in excess of 0.5 g/dL, and 10% were nephrotic. Glomerular changes seen at autopsy in 36 patients included frequent mesangial lesions and depo
Thrombocytopenic purpura has recently been noted in sexually active homosexual men. To elucidate the pathogenesis of thrombocytopenic purpura in this population, we compared the disorder in 33 homosexual men with that in 23 patients (15 women and 8 men) thought to have classic autoimmune thrombocytopenic purpura. The
Payan MJ; Gambarelli D; Routy JP; Choux R; Blanc AP; Alliez B; Toga I
A typical case of acquired immune deficiency syndrome (AIDS) has been clinically and morphologically studied. This homosexual man whose past history was significant for i.v. drug abuse and sexually transmitted infection presented several opportunistic infections with a profound impairment of cell-mediated immunity. Au
Cavaille-Coll M; Messiah A; Klatzmann D; Rozenbaum W; Lachiver D; Kernbaum S; Brisson E; Chapuis F; Blanc C; Debre P; et al
In order to determine whether there exists a distinct immunological profile that discriminates between healthy homosexual men and those expressing persistent generalized hyperplastic lympadenopathy GHL and which of the observed abnormalities in GHL would be most indicative of patients who would eventually develop AIDS
Fourteen heterosexual inmates who developed acquired immunodeficiency syndrome (AIDS) while incarcerated in New York state prisons were studied. All 14 had regularly used illicit drugs intravenously in New York City prior to imprisonment. Leukocyte counts on admission to the state prison system--when all of these inma
The lung and axillary lymph node biopsies of a 33-year-old male drug-abuser with clinical and immunologic evidences of AIDS were studied by light and electron microscopy. Encysted Pneumocystis carinii organisms with attached membranous expansions and virus-like particles were demonstrated in the alveolar spaces and, o
We report three cases of primary intestinal cryptosporidiosis with bilateral interstitial pneumonia. The diagnoses were made using two rapid (one-minute) staining procedures, modified cold Kinyoun s solution and a Hemacolor set, on touch preparations of lung biopsy material, sputum, and stool. Intracellular cryptospor
Klin Wochenschr. 1984 Jun 1;62(11):512-22. Unique Identifier : AIDSLINE MED/84293644
Wofsy CB; Mills J
The Acquired Immune Deficiency Syndrome (AIDS) is a new disease which first appeared in human populations about 1979. The disease is defined by the development of unusual types of cancer (e.g. Kaposi s sarcoma), or severe cellular immunodeficiency manifested by opportunistic infections (e.g. Pneumocystis carinii infec
The development of leukemia/lymphoma in euthymic and congenitally thymus-deficient (nude) mice infected with Friend murine leukemia virus (Friend MuLV) was investigated; both groups developed fatal leukemias within 2-4 months post-infection but the gross and micropathology of lymphoid organs, coupled with cell-surface
Wien Klin Wochenschr. 1984 May 25;96(11):426-7. Unique Identifier : AIDSLINE MED/84302201
Auhuber I; Gattringer C; Wachter H; Huber C
This case report deals with a description of the first case of AIDS in Tirol. Our patient was an intravenous drug abuser and presented with both opportunistic infections (candidiasis, interstitial pneumonia due to Pneumocystis carinii) and with Kaposi s sarcoma. He died within 4 weeks as a result of staphylococcal sep
Am J Med. 1984 Sep;77(3):579-80. Unique Identifier : AIDSLINE MED/84304273
Taylor MN; Baddour LM; Alexander JR
Disseminated histoplasmosis developed in a previously healthy man as the initial manifestation of the acquired immune deficiency syndrome. Following apparently successful therapy with intravenous amphotericin B, he presented two months later with a subacute pneumonitis syndrome diagnosed by bronchoscopy as Pneumocysti
We analyzed the neurological complications in 25 patients with Kaposi s sarcoma, 5 encountered at Memorial Sloan-Kettering Cancer Center and 20 culled from the literature. Patients with all clinical forms of Kaposi s sarcoma [14 classical cases, 2 African cases, 5 cases associated with immunosuppressive therapy and 4
Cancer Immunol Immunother. 1984;17(2):130-4. Unique Identifier : AIDSLINE MED/84282319
Lotzova E; Savary CA; Hersh EM; Khan AA; Rosenblum M
We have investigated the effect of isobutyl nitrite on murine NK-cell antitumor-directed cytotoxicity. This agent has been suggested as one of the factors underlying immunodeficiency syndrome (AIDS) in man. We demonstrated that two injections, each of 0.25 ml isobutyl nitrite, resulted in significant depression of end
Br Med J (Clin Res Ed). 1984 Sep 8;289(6445):573-5. Unique Identifier : AIDSLINE MED/84281683
Melbye M; Biggar RJ; Ebbesen P; Sarngadharan MG; Weiss SH; Gallo RC; Blattner WA
Sera taken from 250 Danish homosexual men in December 1981 as part of a prospective study of the acquired immunodeficiency syndrome (AIDS) were examined for the presence of HTLV-III antibody with an enzyme-linked immunosorbent assay. Antibody was present in 22 (8.8%) of the men. Seropositivity was most strongly associ
Cancer Res. 1984 Oct;44(10):4470-5. Unique Identifier : AIDSLINE MED/84282370
Kleinerman ES; Zicht R; Sarin PS; Gallo RC; Fidler IJ
Culture supernatant fluids from the human T-cell leukemia virus-positive cell line C10/MJ-2 were found to contain a soluble factor with macrophage-activating factor (MAF) activity. The MAF activity of this culture supernatant fluid was stable at 100 degrees for 2 min and was unaffected by treatment with human anti-gam
Miyoshi I; Fujishita M; Yoshimoto S; Kubonishi I; Taguchi H; Ohtsuki Y; Tanioka Y
Transfusion of 15 ml of blood from a rhesus monkey seropositive for human T-cell leukemia virus (HTLV) antigens to an anti-HTLV negative rhesus monkey resulted in the seroconversion of the recipient after five weeks. Cultured peripheral lymphocytes from the seroconverted monkey expressed HTLV antigens and type C virus
Miyoshi I; Kubonishi I; Yoshimoto S; Ohtsuki Y; Akagi T
A rabbit lymphoid cell line transformed by human T-cell leukemia virus (HTLV) was inoculated into the peritoneal cavity of six newborn hamsters treated by antilymphocyte serum. All of them developed lethal tumors two weeks after implantation. The tumor cells were chromosomally of rabbit type, and harbored HTLV and HTL
A mouse hybridoma cell line, H15, produced monoclonal antibody reacting with all the adult T-cell leukemia (ATL) virus (ATLV)-bearing cell lines but none of the ATLV-negative cell lines tested. Binding of H15 antibody to ATLV-bearing cell surfaces was specifically blocked by anti-ATLV positive human sera. Radioimmunop
Int J Cancer. 1984 Aug 15;34(2):215-9. Unique Identifier : AIDSLINE MED/84287956
Biggar RJ; Saxinger C; Gardiner C; Collins WE; Levine PH; Clark JW; Nkrumah FK; Blattner WA
The prevalence of antibodies against the newly described human T-cell lymphoma virus, type I (HTLV-I) in two communities in Ghana , West Africa, is described. There was no difference by community (urban, 3.6% and rural, 4.0%). Prevalence increased with age, being 5.9% among persons g
Int J Cancer. 1984 Aug 15;34(2):221-8. Unique Identifier : AIDSLINE MED/84287957
Sugamura K; Fujii M; Kannagi M; Sakitani M; Takeuchi M; Hinuma Y
Human T-cell leukemia/lymphoma virus (HTLV)-carrying cells from various origins were characterized by cell surface markers and expression of HTLV antigens. Eight cell lines named TCL were obtained by transformation of peripheral blood leukocytes (PBL) of healthy donors or HTLV carriers in cocultures with HTLV-producer
The oncogene of simian sarcoma virus, v-sis, encodes a protein which is homologous to human platelet-derived growth factor (PDGF). This v-sis-encoded protein was expressed in bacteria using an inducible promotor of lambda phage. Soluble extracts from these bacteria contained a substance which competed with 125I-PDGF f
Kobayashi N; Koyanagi Y; Yamamoto N; Hinuma Y; Sato H; Okochi K; Hatanaka M
Human T-cell leukemia virus producer cell line MT-2 was labeled with [32P]phosphoric acid, and its cell extracts were immunoprecipitated with mouse monoclonal antibodies (GIN-7, and KK-1) and rabbit sera (anti-p24, and anti-gp68). Analysis of the immunocomplexes on sodium dodecyl sulfate-polyacrylamide gell electropho
Sera from Australian homosexual men with idiopathic lymphadenopathy syndrome (ILS), a disease related to the acquired immune deficiency syndrome (AIDS), were tested for antibodies to two serotypes of human T leukaemia virus (HTLV), types I and III; type III is the type recently recognized in the USA as being associate
Med Microbiol Immunol (Berl). 1984;173(1):57-64. Unique Identifier : AIDSLINE MED/84295074
Yamamoto N; Hayami M; Komuro A; Schneider J; Hunsmann G; Okada M; Hinuma Y
The experimental infection of six cynomolgus monkeys with adult T-cell leukemia virus (ATLV) was attempted. Three animals were inoculated with living MT-2 cells and three with cell-free ATLV. All animals developed an antibody response to virus-specific glycopolypeptides and viral core polypeptides. ATLV-specific antig
Science. 1984 Aug 24;225(4664):840-2. Unique Identifier : AIDSLINE MED/84300260
Levy JA; Hoffman AD; Kramer SM; Landis JA; Shimabukuro JM; Oshiro LS
Infectious retroviruses have been detected in 22 of 45 randomly selected patients with acquired immune deficiency syndrome (AIDS) and in other individuals from San Francisco. The AIDS-associated retroviruses (ARV) studied in detail had a type D morphology, Mg2+-dependent reverse transcriptase, and cytopathic effects o
Science. 1984 Aug 31;225(4665):927-30. Unique Identifier : AIDSLINE MED/84300271
Arya SK; Gallo RC; Hahn BH; Shaw GM; Popovic M; Salahuddin SZ; Wong-Staal F
A T lymphotropic virus found in patients with the acquired immune deficiency syndrome (AIDS) or lymphadenopathy syndrome has been postulated to be the cause of AIDS. Immunological analysis of this retrovirus and its biological properties suggest that it is a member of the family of human T-lymphotropic retroviruses kn
Saxinger W; Blattner WA; Levine PH; Clark J; Biggar R; Hoh M; Moghissi J; Jacobs P; Wilson L; Jacobson R; et al
Antibodies specific for human T-cell leukemia-lymphoma virus type I (HTLV-I) were demonstrated in serum samples from various groups of people in South Africa , Uganda , Ghana ,
Mitsuya H; Guo HG; Cossman J; Megson M; Reitz MS Jr; Broder S
Tetanus-toxoid specific helper-inducer T-cell clones, which had been infected and transformed by human T-cell leukemia-lymphoma virus (HTLV-I), were obtained from an antigen-specific human T cell line by using a limiting dilution technique in the presence of the virus. These HTLV-I-infected T-cell clones proliferated
Science. 1984 Oct 5;226(4670):57-61. Unique Identifier : AIDSLINE MED/84300343
Lee TH; Coligan JE; Sodroski JG; Haseltine WA; Salahuddin SZ; Wong-Staal F; Gallo RC; Essex M
Antibodies in sera from patients with adult T-cell leukemia-lymphoma or from healthy carriers of type I human T-cell leukemia virus (HTLV) recognize an antigen of approximately 42 kilodaltons (p42) in cell lines infected with HTLV-I. Radiolabel sequence analysis of cyanogen bromide fragments of p42 led to the conclusi
Science. 1984 Oct 5;226(4670):61-5. Unique Identifier : AIDSLINE MED/84300344
Slamon DJ; Shimotohno K; Cline MJ; Golde DW; Chen IS
The human T-cell leukemia viruses HTLV-I and HTLV-II are unique among the transforming retroviruses of vertebrates in their ability to transform human T cells in vitro and in their close association with human malignancies (T-cell lymphomas and leukemia). Their genomes are relatively simple, containing the genes gag,
A male infant in whom multiple recurrent multiorgan infections developed during the first six months of life was found to have combined immunodeficiency. Progressive pulmonary disease developed at age two years; cytomegalovirus (
Ohtsuki Y; Miyoshi I; Yoshimoto S; Takahashi K; Akagi T
Ultrastructures of Japanese monkey (Macaca fuscata)-derived type C virus particles in a monkey lymphoid cell line, expressing adult T-cell leukemia (ATL)-associated antigens, are indistinguishable from those of human ATL-associated virus in human and monkey cell lines.
Lancet. 1984 Aug 18;2(8399):370-2. Unique Identifier : AIDSLINE MED/84294239
Armstrong JA; Horne R
Follicular labyrinthine foci, consisting of an association of retrovirus-like particles with expanded dendritic reticular (antigen trapping) cells, are described in lymph nodes from four immunodeficient homosexual men with unexplained persistent lymphadenopathy. One patient has severe acquired immunodeficiency syndrom
2000 persons in the UK were examined serologically for antibodies to human T-lymphotropic virus type III (HTLV-III). Sera reacting in a membrane immunofluorescence assay (IFA) to HTLV-III were also positive when tested against cells infected with lymphadenopathy virus (LAV-1), and cross-adsorption tests indicated that
Gazzard BG; Shanson DC; Farthing C; Lawrence AG; Tedder RS; Cheingsong-Popov R; Dalgleish A; Weiss RA
Between 1980 and 1984 28 homosexual men who had had ano-genital intercourse with patients with either acquired immunodeficiency syndrome (AIDS) or persistent generalised lymphadenopathy (PGL) were followed up. The pattern of the sexual links indicated that within this group there were two clusters, one consisting of 7
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