Compared to healthy homosexual and heterosexual men, homosexual men with acquired immune deficiency syndrome (AIDS) possessed significantly higher levels of IgG antibody to the neutral glycolipid asialo GM1 (ganglio-N-tetraosylceramide) (P less than 0.01). Of 31 homosexuals with AIDS, 36% possessed levels of this anti
Radin DR; Rosenstein H; Boswell WD; Ralls PW; Halls JM
An unusual case of Burkitt lymphoma presenting with an osteolytic pelvic lesion in a homosexual man with acquired immune deficiency syndrome (AIDS) is reported. Computed tomography (CT) demonstrated unsuspected renal involvement and was used for guided percutaneous biopsy. The CT appearance of renal Burkitt lymphoma w
JAMA. 1984 Jan 13;251(2):242-6. Unique Identifier : AIDSLINE MED/84090519
Miller B; Stansfield SK; Zack MM; Curran JW; Kaplan JE; Schonberger LB; Falk H; Spira TJ; Mildvan D
To establish whether the syndrome of unexplained generalized lymphadenopathy in homosexual men was new and related epidemiologically to the acquired immune deficiency syndrome (AIDS), we reviewed 3,139 pathology reports of lymph node biopsies performed at seven hospitals in New York City during the years 1977 through
Abdominal computed tomography (CT) was performed in 31 patients with Kaposi sarcoma (KS) related to acquired immunodeficiency syndrome (AIDS), three patients with classic KS, and 12 patients with the newly described lymphadenopathy syndrome (LNS). The frequency, distribution, and appearance of lymphadenopathy and sple
A syndrome of acquired immunodeficiency within a group of outdoor-housed rhesus macaques (Macaca mulatta) with unusually high mortality has been identified at the California Primate Research Center. The cause of death for most of the affected animals included septicemia and/or chronic diarrhea with wasting, often comp
Am J Psychiatry. 1984 Jan;141(1):95-6. Unique Identifier : AIDSLINE MED/84101896
Nurnberg HG; Prudic J; Fiori M; Freedman EP
The authors report the case of a man with acquired immune deficiency syndrome (AIDS) who was admitted to the hospital because of an organic mental syndrome with affective and delusional features.
Ann Intern Med. 1984 Jan;100(1):36-42. Unique Identifier : AIDSLINE MED/84102718
Wong B; Gold JW; Brown AE; Lange M; Fried R; Grieco M; Mildvan D; Giron J; Tapper ML; Lerner CW; et al
Central-nervous-system toxoplasmosis developed in 7 of 269 patients with the acquired immunodeficiency syndrome reported to the New York City Health Department through July 1982. Focal neurologic abnormalities, mass lesions on computed-tomographic brain scans, lymphocytic cerebrospinal fluid pleocytosis, and detectabl
Peripheral blood and bone marrow findings are presented for six homosexual males with Kaposi s sarcoma. Cytopenia in one or more cell lines was common in this group of patients, including two individuals with pancytopenia. Bone marrow findings in all patients, while not specific, were similar in that adequate numbers
A homosexual man with A.I.D.S. (acquired immunologic deficiency syndrome) and pneumocystis infestation was found to have diffuse Ga-67 uptake in the lungs with a coincident negative chest x-ray. While Ga-67 accumulates diffusely in the lungs in a variety of conditions, the present case is the first described in a pati
Ciobanu N; Welte K; Kruger G; Venuta S; Gold J; Feldman SP; Wang CY; Koziner B; Moore MA; Safai B; et al
We studied the ability of phytohemagglutinin (PHA) and two anti-T-cell monoclonal antibodies OKT3 and Pan T2, to induce proliferation and interleukin 2 (IL2) production in peripheral blood lymphocytes (PBL) from 21 homosexual patients: 12 with Kaposi s sarcoma (KS), 4 with reactive lymphadenopathy, and 5 with opportun
Natural killer cell function, directed against either K562 tumor targets or herpes simplex virus type 1-infected fibroblasts, was often low in patients with acquired immune deficiency syndrome (AIDS) but failed to distinguish these patients from either male homosexual controls or patients with lymphadenopathy. Mononuc
N Engl J Med. 1984 Jan 12;310(2):69-75. Unique Identifier : AIDSLINE MED/84093434
Curran JW; Lawrence DN; Jaffe H; Kaplan JE; Zyla LD; Chamberland M; Weinstein R; Lui KJ; Schonberger LB; Spira TJ; et al
Of 2157 patients with the acquired immunodeficiency syndrome (AIDS) whose cases were reported to the Centers for Disease Control by August 22, 1983, 64 (3 per cent) with AIDS and Pneumocystis carinii pneumonia had no recognized risk factors for AIDS. Eighteen of these (28 per cent) had received blood components within
N Engl J Med. 1984 Jan 12;310(2):76-81. Unique Identifier : AIDSLINE MED/84093435
Scott GB; Buck BE; Leterman JG; Bloom FL; Parks WP
Fourteen infants with clinical and laboratory features of an acquired immunodeficiency syndrome were identified in a single metropolitan area from November 1980 to July 1983. Patients were predominantly of Haitian parentage, although two cases occurred in offspring of non-Haitian intravenous drug abusers. Only one pat
Ann Intern Med. 1984 Jan;100(1):107-14. Unique Identifier : AIDSLINE MED/84102686
Gnepp DR; Chandler W; Hyams V
Kaposi s sarcoma is a cutaneous neoplasm commonly arising in the extremities, and rarely in the mucosa or skin of the head and neck. We discuss nine cases of Kaposi s sarcoma arising in the head and neck region, retrieved from the files of the Armed Forces Institute of Pathology, together with 74 cases from the litera
A bovine calici-like virus and astrovirus, present in the same fecal sample from an outbreak of diarrhea, were separated from each other by calf passage. The calici-like virus (Newbury agent SRV-1) caused anorexia, diarrhea, and xylose malabsorption in gnotobiotic calves aged 17 to 60 days, whereas the bovine astrovir
We have evaluated the functional properties of the OK-T8+/OKT4+ T-cell subpopulations in nine patients with a new syndrome of acquired immune deficiency (AIDS). Despite polyclonal hypergammaglobulinemia in the sera of these patients, their peripheral blood lymphocytes (PBL) produced negligible quantities of immunoglob
Nicholson JK; McDougal JS; Spira TJ; Cross GD; Jones BM; Reinherz EL
Unexplained, generalized lymphadenopathy in homosexual men, which can be a prodrome to the acquired immunodeficiency syndrome, is associated with impaired cell-mediated immunity, a low ratio of T helper-inducer to T suppressor-cytotoxic cells (defined by the T4 and T8 monoclonal antibodies), and hypergammaglobulinemia
JAMA. 1984 Jan 13;251(2):237-41. Unique Identifier : AIDSLINE MED/84090518
Mavligit GM; Talpaz M; Hsia FT; Wong W; Lichtiger B; Mansell PW; Mumford DM
Putative, sperm-induced allogeneic immunization was correlated with immune dysregulation in a study of 30 asymptomatic, monogamously paired homosexual males. Evidence for allogeneic immunization existed among 19 of 26 homosexual males who were anal sperm recipients. No evidence for any form of alloimmunization was fou
Am J Med. 1984 Jan;76(1):95-100. Unique Identifier : AIDSLINE MED/84101557
Fahey JL; Prince H; Weaver M; Groopman J; Visscher B; Schwartz K; Detels R
Quantitative measurements of the immune cell subgroups, T helper (Leu 3+/OKT4+) cells and T suppressor/cytotoxic (Leu 2+/OKT8+) cells, were made in patients having acquired immune deficiency syndrome (AIDS) with Kaposi s sarcoma and in patients with AIDS and opportunistic infection, as well as in three other relevant
Ann Intern Med. 1984 Jan;100(1):62-5. Unique Identifier : AIDSLINE MED/84102723
Pitchenik AE; Shafron RD; Glasser RM; Spira TJ
A 71-year-old previously healthy woman developed unexplained thrush , onychomycosis, Pneumocystis carinii pneumonia, and a T-cell defect consistent with the acquired immunodeficiency syndrome. Her only apparent risk factor was infrequent, monogamous sexual contact with her husba
Ann Intern Med. 1984 Feb;100(2):173-7. Unique Identifier : AIDSLINE MED/84102732
Gascon P; Zoumbos NC; Young NS
Concern for the potential risk of the acquired immunodeficiency syndrome among blood cell recipients led us to measure immunologic functions in patients who had received multiple transfusions. Abnormalities of two immunologic tests, natural killer cell function and helper/suppressor (T4/T8) lymphocyte subpopulation ra
J Cancer Res Clin Oncol. 1983;106(3):240-3. Unique Identifier : AIDSLINE MED/84088032
Ohtsuki Y; Akagi T; Takahashi K; Miyoshi I
In an attempt to demonstrate the presence of antibodies to ATL-associated type-C virus particles (ATLV), an indirect immunoferritin method of immunoelectron microscopy was performed on an ATLV-producing human cord T-cell line (MT-2) and short-term cultures of ATL cells. All five sera from ATL patients seropositive to
A glycosylated protein of approximately 70,000 daltons (gp70) from the surface of human peripheral blood T cells was immunoprecipitated by antisera to the baboon endogenous retrovirus (BEV-M7) and the serologically related feline endogenous retrovirus (RD114) but not by antisera to other retroviruses. Whereas prelimin
Andiman W; Gradoville L; Heston L; Neydorff R; Savage ME; Kitchingman G; Shedd D; Miller G
Cloned fragments of the Epstein-Barr virus (EBV) genome were used to examine tissues from 145 patients for the presence of EBV DNA by two techniques: (1) nucleic acid hybridization of cell spots from which the DNA had been extracted in situ and (2) hybridization of DNA that had been transferred to nitrocellulose by So
Nature. 1984 Jan 12-18;307(5947):180-3. Unique Identifier : AIDSLINE MED/84093622
Niman HL
It has recently been reported that the sequences of the sis oncogene of simian sarcoma virus (SSV) and of human platelet-derived growth factor (PDGF) are very similar, establishing the most solid link yet between the mitogenic actions of growth factors and the transforming proteins of retroviruses. To investigate mole
Public Health Rep. 1983 Nov-Dec;98(6):559-65. Unique Identifier : AIDSLINE MED/84096228
Taube S; Goldberg M
In order to define the clinical syndrome of AIDS and begin to deal with it effectively, scientists needed to understand how the immune system works. Fortunately, considerable knowledge was available: research in immunology over the last two decades had provided the technological advances and basic information about ce
Science. 1984 Jan 6;223(4631):74-6. Unique Identifier : AIDSLINE MED/84097516
Gravell M; London WT; Houff SA; Madden DL; Dalakas MC; Sever JL; Osborn KG; Maul DH; Henrickson RV; Marx PA; et al
Simian acquired immunodeficiency syndrome (SAIDS), a disease clinically and pathologically similar to acquired immunodeficiency syndrome in humans, was transmitted from diseased rhesus monkeys (Macaca mulatta) to normal monkeys by inoculation with heparinized whole blood or plasma that had been passed through filters
T-cell growth factor (TCGF) or interleukin-2 ( IL-2 ), an immunoregulatory lymphokine, is produced by lectin- or antigen-activated mature T lymphocytes and in a constitutive manner by certain T-cell lymphoma cell lines. By means of a molecular clone of human TCGF and DNA
Science. 1984 Feb 3;223(4635):487-91. Unique Identifier : AIDSLINE GENBANK/K01402
Josephs SF; Guo C; Ratner L; Wong-Staal F
The nucleotide sequences of the six regions within the normal human cellular locus (c-sis) that correspond to the entire transforming region of the simian sarcoma virus (SSV) genome (v-sis) were determined. The regions are bounded by acceptor and donor splice sites and, except for region 6, resemble exons. Region 6 la
Twenty five cases of Burkitt s lymphoma in Thai children were diagnosed at the Department of Pediatrics, Siriraj Hospital during the period of 13 years (January 1969 to April 1982). Males were more affected than females with the ratio of 1.7:1. The age ranged from 2 to 11 years with the median age of 4-5 years. The mo
Melbye M; Biggar RJ; Ebbesen P; Andersen HK; Vestergaard BF
Two-hundred and fifty-nine male homosexuals (HS) of a large and a small Danish town were studied for antibodies to various virus and their statistical relationship to sex habits, drug use and other lifestyle factors. Prevalence rates against cytomegalovirus (
The authors used a method that includes Giemsa-stained touch preparations of a lung biopsy and culture of the same biopsy for viruses and microorganisms. The yield of etiologic agent diagnoses by this cytologic method was compared with yield from a simultaneous biopsy processed by usual histologic methods and stained
The lungs of 17 homosexual males who died of the acquired immune deficiency syndrome were studied to determine the type and extent of pulmonary disease present at autopsy. All patients had two or more pathologic processes, including one or more infections in their lungs. Cytomegalovirus pneumonia was the most common p
Ann Intern Med. 1984 Jan;100(1):92-106. Unique Identifier : AIDSLINE MED/84102731
Fauci AS; Macher AM; Longo DL; Lane HC; Rook AH; Masur H; Gelmann EP
The acquired immunodeficiency syndrome is a new disease whose cause is unknown but is almost surely due to a transmissible agent, most likely a virus. The disease is clearly spread by sexual contact, particularly homosexual activity. Blood-borne transmission constitutes the other major recognized form of spread of the
Ann Intern Med. 1984 Feb;100(2):178-82. Unique Identifier : AIDSLINE MED/84102733
Kreiss JK; Lawrence DN; Kasper CK; Goldstein AL; Naylor PH; McLane MF; Lee TH; Essex M
Recently, antibodies to human T-cell leukemia virus membrane antigens (HTLV-MA) and elevated levels of beta 2-microglobulin and thymosin alpha 1 have been found with high frequency in patients with the acquired immunodeficiency syndrome. Prospective studies of asymptomatic persons at high risk for this syndrome will a
Homosexual and heterosexual patients with the acquired immunodeficiency syndrome were compared by risk group. Race; diagnoses; history of sexually transmitted diseases, sexual behavior, and drug use; and socioeconomic indicators differed considerably among risk groups, suggesting different risk factors for acquisition
Biochem Biophys Res Commun. 1983 Nov 30;117(1):176-82. Unique Identifier : AIDSLINE MED/84104195
Betsholtz C; Heldin CH; Nister M; Ek B; Wasteson A; Westermark B
Several human normal and neoplastic cell lines were screened for production of PDGF receptor competing activity. Conditioned medium from two sarcomas and one glioma blocked 125I-PDGF binding to human foreskin fibroblasts in a dose-dependent manner. In each case this effect was abolished when the conditioned medium was
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