Cytomegalovirus retinitis: a manifestation of the acquired immune deficiency syndrome (AIDS). NLM AIDSLINE Important note: Information in this article was accurate in 1983. The state of the art may have changed since the publication date.

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Cytomegalovirus retinitis: a manifestation of the acquired immune deficiency syndrome (AIDS).

Br J Ophthalmol. 1983 Jun;67(6):372-80. Unique Identifier : AIDSLINE MED/83204728
Friedman AH; Orellana J; Freeman WR; Luntz MH; Starr MB; Tapper ML; Spigland I; Roterdam H; Mesa Tejada R; Braunhut S; Mildvan D; Mathur U

Abstract: Two homosexual males with the gay bowel syndrome' experienced an acute unilateral loss of vision. Both patients had white intraretinal lesions, which became confluent. One of the cases had a depressed cell-mediated immunity; both patients ultimately died after a prolonged illness. In one patient cytomegalovirus was cultured from a vitreous biopsy. Autopsy revealed disseminated cytomegalovirus in both patients. Widespread retinal necrosis was evident, with typical nuclear and cytoplasmic inclusions of cytomegalovirus. Electron microscopy showed herpes virus, while immunoperoxidase techniques showed cytomegalovirus. The altered cell-mediated response present in homosexual patients may be responsible for the clinical syndromes of Kaposi's sarcoma and opportunistic infection by Pneumocystis carinii, herpes simplex, or cytomegalovirus.
Keywords: Acquired Immunodeficiency Syndrome/*COMPLICATIONS Adult Case Report Cytomegalovirus/ISOLATION & PURIF Cytomegalovirus Infections/*ETIOLOGY/PATHOLOGY Fluorescein Angiography Homosexuality Human Male Retina/PATHOLOGY Retinitis/*ETIOLOGY/MICROBIOLOGY/PATHOLOGY Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. Vitreous Body/MICROBIOLOGY JOURNAL ARTICLE

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Copyright © 1983 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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