Identification of circulating maternal T and B lymphocytes in uncomplicated severe combined immunodeficiency by HLA typing of subpopulations of T cells separated by the fluorescence-activated cell sorter and of Epstein Barr virus-derived B cell lines.

Important note: Information in this article was accurate in 1983. The state of the art may have changed since the publication date.

J Immunol. 1983 Jun;130(6):2493-5. Unique Identifier : AIDSLINE MED/83214545
Geha RS; Reinherz E

Abstract: Circulating maternal T cells were sought in a child with severe combined immunodeficiency (SCID) and no evidence of acute graft-vs-host disease, but who had small numbers (9 to 11%) of circulating T3-positive cells. HLA typing of unfractionated peripheral blood lymphocytes (PBL) and of isolated E rosette-forming cells (37 to 44% of PBL) failed to reveal the presence of maternal lymphocytes. T3-positive cells isolated by the fluorescence-activated cell sorter, however, expressed exclusively maternal HLA antigens. A lymphoblastoid B cell line established by infecting the patient's PBL with Epstein Barr virus then expressed exclusively maternal HLA antigens. The presence of maternal T and B cells in uncomplicated SCID may be more common than thought previously and calls for a careful assessment of the origin of any mature T cells that are present in affected infants. In addition, the presence of maternal cells in SCID may complicate the infant's therapy.

Keywords: B-Lymphocytes/*IMMUNOLOGY Cell Line Cell Separation Cell Transformation, Viral Female Flow Cytometry Herpesvirus 4, Human/IMMUNOLOGY Histocompatibility Testing Human HLA Antigens/ANALYSIS *Immunity, Maternally-Acquired Immunologic Deficiency Syndromes/GENETICS/*IMMUNOLOGY Infant Male Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. T-Lymphocytes/CLASSIFICATION/*IMMUNOLOGY JOURNAL ARTICLE

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