Transient immunodeficiency during asymptomatic Epstein-Barr virus infection. NLM AIDSLINE Important note: Information in this article was accurate in 1983. The state of the art may have changed since the publication date.

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Transient immunodeficiency during asymptomatic Epstein-Barr virus infection.

Pediatrics. 1983 Jun;71(6):964-7. Unique Identifier : AIDSLINE MED/83220615
Bowen TJ; Wedgwood RJ; Ochs HD; Henle W

Abstract: In vivo and in vitro humoral and cellular immune responses were studied in a 2 1/2-year-old girl immediately before, during, and after an asymptomatic infection with Epstein-Barr virus. During the acute EBV infection, the patient's peripheral blood mononuclear cells were deficient in immunoglobulin synthesis and suppressed the in vitro immunoglobulin synthesis of normal allogeneic cells. In vitro mitogen transformation of lymphocytes was reduced. In vivo antibody responses to the T cell-dependent antigens bacteriophage phi X 174 and Keyhole limpet hemocyanin were markedly depressed. These studies suggest that suppressor cells induced during acute EBV infection not only suppress immunoglobulin synthesis in vitro, but also interfere with in vivo antibody synthesis.
Keywords: Antibodies, Viral/ANALYSIS B-Lymphocytes/IMMUNOLOGY Case Report Child, Preschool Female Herpesviridae Infections/*IMMUNOLOGY Herpesvirus 4, Human Human IgG/BIOSYNTHESIS IgM/BIOSYNTHESIS Immunologic Deficiency Syndromes/ETIOLOGY/*IMMUNOLOGY Lymphocyte Transformation Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. T-Lymphocytes, Suppressor-Effector/IMMUNOLOGY JOURNAL ARTICLE

KWDantibodies,viral/analysisb-lymphocytes/immunologycasereportchild,preschoolfemaleherpesviridaeinfections/KWDimmunologyherpesvirus4,humanhumanigg/biosynthesisigm/biosynthesisimmunologicdeficiencysyndromes/etiology/KWDimmunologylymphocytetransformationsupport,non-uKWDsKWDgov'tsupport,uKWDsKWDgov't,pKWDhKWDsKWDt-lymphocytes,suppressor-effector/immunologyjournalarticle
830930
M8390012

Copyright © 1983 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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