Simian sarcoma virus onc gene, v-sis, is derived from the gene (or genes) encoding a platelet-derived growth factor. NLM AIDSLINE Important note: Information in this article was accurate in 1983. The state of the art may have changed since the publication date.

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Simian sarcoma virus onc gene, v-sis, is derived from the gene (or genes) encoding a platelet-derived growth factor.

Science. 1983 Jul 15;221(4607):275-7. Unique Identifier : AIDSLINE MED/83223635
Doolittle RF; Hunkapiller MW; Hood LE; Devare SG; Robbins KC; Aaronson SA; Antoniades HN

Abstract: The transforming protein of a primate sarcoma virus and a platelet-derived growth factor are derived from the same or closely related cellular genes. This conclusion is based on the demonstration of extensive sequence similarity between the transforming protein derived from the simian sarcoma virus onc gene, v-sis, and a human platelet-derived growth factor. The mechanism by which v-sis transforms cells could involve the constitutive expression of a protein with functions similar or identical to those of a factor active transiently during normal cell growth.
Keywords: Amino Acid Sequence Animal Cebidae Cell Transformation, Neoplastic/METABOLISM Genes Growth Substances/*GENETICS/PHYSIOLOGY Human *Oncogenes Peptides/*GENETICS/PHYSIOLOGY Retroviridae/*GENETICS Sarcoma Viruses, Simian/*GENETICS Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. JOURNAL ARTICLE

KWDaminoacidsequenceanimalcebidaecelltransformation,neoplastic/metabolismgenesgrowthsubstances/KWDgenetics/physiologyhumanKWDoncogenespeptides/KWDgenetics/physiologyretroviridae/KWDgeneticssarcomaviruses,simian/KWDgeneticssupport,non-uKWDsKWDgov'tsupport,uKWDsKWDgov't,pKWDhKWDsKWDjournalarticle
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M8390010

Copyright © 1983 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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