Significance of viral infections in severe combined immunodeficiency disease. NLM AIDSLINE Important note: Information in this article was accurate in 1983. The state of the art may have changed since the publication date.

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Significance of viral infections in severe combined immunodeficiency disease.

Pediatr Infect Dis. 1983 May-Jun;2(3):187-92. Unique Identifier : AIDSLINE MED/83246846
Jarvis WR; Middleton PJ; Gelfand EW

Abstract: An analysis of a prospective study of viral infections in 12 patients with severe combined immunodeficiency is presented. Infections of viral etiology were common, with pulmonary and gastrointestinal infections being most frequent. Fourteen of 25 infections (56%) were nonsocomially acquired and 10 of 25 (40%) were community-acquired. The period of symptomatology and the duration of viral excretion were usually prolonged beyond those associated with disease in the general pediatric population. Pulmonary infections were associated with considerable morbidity and mortality. Gastrointestinal infections disrupted gastrointestinal function and possibly played a role in enteric Gram-negative bacillary sepsis. The inability of these patients to eradicate these viruses in the absence of immunologic reconstitution resulted in significant morbidity, often with a fatal outcome.
Keywords: Cross Infection/DIAGNOSIS/EPIDEMIOLOGY Gastroenteritis/DIAGNOSIS/EPIDEMIOLOGY/ETIOLOGY Human Immunologic Deficiency Syndromes/*COMPLICATIONS/IMMUNOLOGY Pneumonia, Viral/DIAGNOSIS/EPIDEMIOLOGY/ETIOLOGY Prospective Studies Viremia/DIAGNOSIS/EPIDEMIOLOGY Virus Diseases/EPIDEMIOLOGY/*ETIOLOGY/MORTALITY JOURNAL ARTICLE

KWDcrossinfection/diagnosis/epidemiologygastroenteritis/diagnosis/epidemiology/etiologyhumanimmunologicdeficiencysyndromes/KWDcomplications/immunologypneumonia,viral/diagnosis/epidemiology/etiologyprospectivestudiesviremia/diagnosis/epidemiologyvirusdiseases/epidemiology/KWDetiology/mortalityjournalarticle
831030
M83A0041

Copyright © 1983 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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