Interferon-induced alterations in cells: relevance to viral and nonviral diseases. NLM AIDSLINE Important note: Information in this article was accurate in 1983. The state of the art may have changed since the publication date.

Click here to return to AIDSLINE main menu
DonateNow
Print this Article


Interferon-induced alterations in cells: relevance to viral and nonviral diseases.

Lab Invest. 1983 Jul;49(1):4-18. Unique Identifier : AIDSLINE MED/83242889
Preble OT; Friedman RM

Abstract: Thus, interferon has diverse effects on cellular structure and/or function. Although some of these effects may be involved in interferon's antiviral actions, they may also play a role in normal physiologic processes. Inappropriate production of or response to interferon may, therefore, contribute to abnormal cell-cell interactions seen in a variety of disease states. In view of the increasingly widespread use of human interferons in antiviral and anticancer therapy, further investigation is needed to understand the many effects of interferons on cells. For example, insight into the biologic properties of each of the numerous subspecies of alpha-interferon may allow more rational decisions about the type of interferon, dose, and administration schedule necessary for maximal beneficial effects in cancer patients. Further studies on the immunoregulatory effects of the different types of interferons are also necessary to elucidate whether interferon is involved in the pathophysiology of immune disorders.
Keywords: Acquired Immunodeficiency Syndrome/IMMUNOLOGY Acute Disease Animal Autoimmune Diseases/IMMUNOLOGY Cell Differentiation/DRUG EFFECTS Cell Division/DRUG EFFECTS Cells/*DRUG EFFECTS Chemistry Cytochrome P-450/METABOLISM Human Immunologic Diseases/IMMUNOLOGY/PATHOLOGY Interferons/BIOSYNTHESIS/*PHYSIOLOGY Subcellular Fractions/PATHOLOGY Support, Non-U.S. Gov't Support, U.S. Gov't, Non-P.H.S. Virus Diseases/*IMMUNOLOGY/PATHOLOGY JOURNAL ARTICLE REVIEW

KWDacquiredimmunodeficiencysyndrome/immunologyacutediseaseanimalautoimmunediseases/immunologycelldifferentiation/drugeffectscelldivision/drugeffectscells/KWDdrugeffectschemistrycytochromep-450/metabolismhumanimmunologicdiseases/immunology/pathologyinterferons/biosynthesis/KWDphysiologysubcellularfractions/pathologysupport,non-uKWDsKWDgov'tsupport,uKWDsKWDgov't,non-pKWDhKWDsKWDvirusdiseases/KWDimmunology/pathologyjournalarticlereview
831030
M83A0030

Copyright © 1983 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1983. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1983. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .