Generalized lymphadenopathy and T cell abnormalities in hemophilia A. NLM AIDSLINE Important note: Information in this article was accurate in 1983. The state of the art may have changed since the publication date.

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Generalized lymphadenopathy and T cell abnormalities in hemophilia A.

J Pediatr. 1983 Jul;103(1):18-22. Unique Identifier : AIDSLINE MED/83240992
Gill JC; Menitove JE; Wheeler D; Aster RH; Montgomery RR

Abstract: Two patients with hemophilia A had generalized lymphadenopathy, lymphopenia, elevated IgG values, depressed T4 (helper) lymphocytes, elevated T8 (suppressor) lymphocytes, and abnormally low T4/T8 ratios. One of the patients, who also had hepatosplenomegaly, underwent cervical lymph node biopsy; the node contained 43% T8-lymphocytes, a marked elevation over the small fraction of T8 cells usually found in lymph nodes. These patients may have a form of the acquired immune deficiency syndrome described in male homosexuals, Haitians, intravenous drug abusers, and recently, in patients with hemophilia. We studied T cell phenotypes in 43 patients with hemophilia. Fourteen of 28 patients given commercial factor VIII concentrates had abnormal T4/T8 ratios; none of nine patients who used cryoprecipitate had abnormal values. T4 helper cells were significantly lower, T8 suppressor cells significantly elevated, and T4/T8 ratios significantly lower in the lyophilized concentrate users and in patients with hemophilia as a total group. The type of therapeutic factor VIII replacement may alter the risk of developing T4/T8 abnormalities or AIDS.
Keywords: Acquired Immunodeficiency Syndrome/TRANSMISSION Case Report Child Comparative Study Factor VIII/ADVERSE EFFECTS Fibrinogen/ADVERSE EFFECTS Hemophilia/COMPLICATIONS/*IMMUNOLOGY/THERAPY Human Leukocyte Count Lymphatic Diseases/*ETIOLOGY Male T-Lymphocytes, Helper-Inducer/*ANALYSIS T-Lymphocytes, Suppressor-Effector/*ANALYSIS JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/transmissioncasereportchildcomparativestudyfactorviii/adverseeffectsfibrinogen/adverseeffectshemophilia/complications/KWDimmunology/therapyhumanleukocytecountlymphaticdiseases/KWDetiologymalet-lymphocytes,helper-inducer/KWDanalysist-lymphocytes,suppressor-effector/KWDanalysisjournalarticle
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Copyright © 1983 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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