Cellular onc genes: their role as progenitors of viral onc genes and their expression in human cells. NLM AIDSLINE Important note: Information in this article was accurate in 1983. The state of the art may have changed since the publication date.

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Cellular onc genes: their role as progenitors of viral onc genes and their expression in human cells.

Hamatol Bluttransfus. 1983;28:178-85. Unique Identifier : AIDSLINE MED/83235780
Wong-Staal F; Josephs S; Dalla-Favera R; Westin E; Gelmann E; Franchini G; Gallo RC

Abstract: Viral transforming (v-onc) genes are derived from cellular (c-onc) genes that are highly conserved among vertebrates. Comparative studies of v-onc and c-onc genes have shed some light on the mechanism leading to formation of the transforming viruses. A specific example of the sis gene is presented here for illustration. Studies on the expression of six c-onc genes in human cells revealed at least three categories of onc genes: (a) those that are universally expressed and probably are important in basic cellular functions, (b) those that are not detectably expressed in the cells examined and may have very transient expression in development, and (c) those that are only expressed in specific cell types and may be important in tissue differentiation. Our studies do not show conclusively a role of these onc genes in human neoplasias.
Keywords: Animal Base Sequence Cell Line *Cell Transformation, Neoplastic Cloning, Molecular DNA Restriction Enzymes *Genes, Viral Hematopoietic Stem Cells/MICROBIOLOGY Human Neoplasms/GENETICS/MICROBIOLOGY *Oncogenes Retroviridae/*GENETICS Sarcoma Viruses, Simian/GENETICS JOURNAL ARTICLE

KWDanimalbasesequencecelllineKWDcelltransformation,neoplasticcloning,moleculardnarestrictionenzymesKWDgenes,viralhematopoieticstemcells/microbiologyhumanneoplasms/genetics/microbiologyKWDoncogenesretroviridae/KWDgeneticssarcomaviruses,simian/geneticsjournalarticle
831030
M83A0024

Copyright © 1983 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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