c-sis is translocated from chromosome 22 to chromosome 9 in chronic myelocytic leukemia. NLM AIDSLINE Important note: Information in this article was accurate in 1983. The state of the art may have changed since the publication date.

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c-sis is translocated from chromosome 22 to chromosome 9 in chronic myelocytic leukemia.

J Exp Med. 1983 Jul 1;158(1):9-15. Unique Identifier : AIDSLINE MED/83240469
Groffen J; Heisterkamp N; Stephenson JR; van Kessel AG; de Klein A; Grosveld G; Bootsma D

Abstract: By analysis of a series of somatic cell hybrids derived by fusion of either mouse or Chinese hamster cells with leukocytes from different chronic myelocytic leukemia (CML) patients or from normal donors, we have localized the human oncogene, c-sis, on the q11 to qter segment of chromosome 22 and demonstrated its translocation from chromosome 22 to chromosome 9 (q34) in CML.
Keywords: Animal *Chromosomes, Human, 21-22 *Chromosomes, Human, 6-12 DNA DNA Restriction Enzymes DNA, Recombinant Hamsters Human Hybrid Cells/ULTRASTRUCTURE Leukemia, Myeloid/*GENETICS Lung Neoplasms/GENETICS Mice Nucleic Acid Hybridization *Oncogenes Sarcoma Viruses, Simian/GENETICS Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. *Translocation (Genetics) JOURNAL ARTICLE

KWDanimalKWDchromosomes,human,21-22KWDchromosomes,human,6-12dnadnarestrictionenzymesdna,recombinanthamstershumanhybridcells/ultrastructureleukemia,myeloid/KWDgeneticslungneoplasms/geneticsmicenucleicacidhybridizationKWDoncogenessarcomaviruses,simian/geneticssupport,non-uKWDsKWDgov'tsupport,uKWDsKWDgov't,pKWDhKWDs
831030
M83A0018

Copyright © 1983 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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