Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus. NLM AIDSLINE Important note: Information in this article was accurate in 1983. The state of the art may have changed since the publication date.

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Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus.

Nature. 1983 Jul 7-13;304(5921):35-9. Unique Identifier : AIDSLINE MED/83244981
Waterfield MD; Scrace GT; Whittle N; Stroobant P; Johnsson A; Wasteson A; Westermark B; Heldin CH; Huang JS; Deuel TF

Abstract: A partial amino acid sequence of human platelet-derived growth factor, the major mitogen in serum for cells of mesenchymal origin, has been determined. A region of 104 contiguous amino acids shows virtual identity with the predicted sequence of p28sis, the putative transforming protein of simian sarcoma virus (SSV). This similarity suggests a mechanism for transformation by SSV and other agents, involving expression of growth factors.
Keywords: Amino Acid Sequence Animal *Cell Transformation, Neoplastic *Genes, Structural *Genes, Viral Growth Substances/*GENETICS/ISOLATION & PURIF Human Macromolecular Systems Molecular Weight Nucleic Acid Hybridization *Oncogenes Peptides/*GENETICS/ISOLATION & PURIF Retroviridae/*GENETICS RNA, Messenger/GENETICS Sarcoma Viruses, Simian/*GENETICS Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. Viral Proteins/*GENETICS JOURNAL ARTICLE

KWDaminoacidsequenceanimalKWDcelltransformation,neoplasticKWDgenes,structuralKWDgenes,viralgrowthsubstances/KWDgenetics/isolation&purifhumanmacromolecularsystemsmolecularweightnucleicacidhybridizationKWDoncogenespeptides/KWDgenetics/isolation&purifretroviridae/KWDgeneticsrna,messenger/geneticssarcomaviruses,simian/KWDgeneticssupport,non-uKWDsKWDgov'tsupport,uKWDsKWDgov't,pKWDhKWDsKWDviralproteins/KWDgeneticsjournalarticle
831030
M83A0017

Copyright © 1983 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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