Immunologic alterations in bronchoalveolar lavage fluid in the acquired immunodeficiency syndrome (AIDS). NLM AIDSLINE Important note: Information in this article was accurate in 1983. The state of the art may have changed since the publication date.

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Immunologic alterations in bronchoalveolar lavage fluid in the acquired immunodeficiency syndrome (AIDS).

Am Rev Respir Dis. 1983 Jul;128(1):189-94. Unique Identifier : AIDSLINE MED/83254244
Rankin JA; Walzer PD; Dwyer JM; Schrader CE; Enriquez RE; Merrill WW

Abstract: The association of Pneumocystis carinii pneumonia and cytomegalovirus infection in apparently healthy intravenous drug abusers or homosexual males recently has been described. Two patients with this syndrome were seen recently at our institution. Bronchoalveolar lavage samples from these two patients, taken at the time of bronchoscopy, were analyzed. In both patients a significant increase in inflammatory cells (polymorphonuclear cells) and evidence for polyclonal B cell activation, as measured by a reverse hemolytic plaque assay was seen compared to normal persons (p less than 0.01 both comparisons). IgM and IgG anti-Pneumocystis carinii antibody titers were elevated in the lavage fluid of one patient each. One patient, originally diagnosed as having Hamman-Rich Syndrome, demonstrated unequivocal chest X-ray improvement with prednisone therapy alone. These observations suggest that the lungs of these two patients were the site of an intense inflammatory response, which was not reflected in studies with peripheral blood.
Keywords: Acquired Immunodeficiency Syndrome/*IMMUNOLOGY Adult Bronchi/*IMMUNOLOGY Case Report Cytomegalovirus Infections/IMMUNOLOGY Homosexuality Human IgA/ANALYSIS IgG/ANALYSIS IgM/ANALYSIS Irrigation Male Pneumonia, Pneumocystis carinii/IMMUNOLOGY Pulmonary Alveoli/*IMMUNOLOGY Pulmonary Fibrosis/IMMUNOLOGY Substance Abuse/IMMUNOLOGY Support, Non-U.S. Gov't Support, U.S. Gov't, Non-P.H.S. Support, U.S. Gov't, P.H.S. Syndrome JOURNAL ARTICLE

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831030
M83A0015

Copyright © 1983 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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