Acquired immune dysfunction in homosexual men: immunologic profiles. NLM AIDSLINE Important note: Information in this article was accurate in 1983. The state of the art may have changed since the publication date.

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Acquired immune dysfunction in homosexual men: immunologic profiles.

Clin Immunol Immunopathol. 1983 Jun;27(3):315-25. Unique Identifier : AIDSLINE MED/83260066
Ammann AJ; Abrams D; Conant M; Chudwin D; Cowan M; Volberding P; Lewis B; Casavant C

Abstract: Homosexual men with Kaposi sarcoma, lymphadenopathy syndrome, opportunistic infection, and nonhomosexual traditional Kaposi sarcoma were evaluated for B cell, T cell, and complement immunity and compared to normal controls and homosexual controls. No significant immunologic abnormalities were found in the traditional Kaposi group. All homosexual groups, including the homosexual controls, had a significant decrease in the helper/suppressor cell ratio. Functional abnormalities of T-cell immunity were observed in the homosexual Kaposi sarcoma, lymphadenopathy syndrome, and opportunistic infection groups. Significant elevations of IgG, IgM, IgA, and IgE were found in the lymphadenopathy group, while only IgG and IgA were elevated in the Kaposi sarcoma group. C3, C4, and immune complexes were normal, while total hemolytic complement activity was increased in the Kaposi sarcoma and lymphadenopathy syndrome groups.
Keywords: Acquired Immunodeficiency Syndrome/COMPLICATIONS/*IMMUNOLOGY B-Lymphocytes/IMMUNOLOGY Complement/ANALYSIS/IMMUNOLOGY *Homosexuality Human Lymphatic Diseases/COMPLICATIONS/IMMUNOLOGY Lymphocyte Culture Test, Mixed Lymphocyte Transformation Male Pneumonia, Pneumocystis carinii/COMPLICATIONS/IMMUNOLOGY Receptors, Antigen, T-Cell/ANALYSIS Sarcoma, Kaposi's/COMPLICATIONS/IMMUNOLOGY Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. T-Lymphocytes/CLASSIFICATION/IMMUNOLOGY T-Lymphocytes, Helper-Inducer/IMMUNOLOGY T-Lymphocytes, Suppressor-Effector/IMMUNOLOGY JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/complications/KWDimmunologyb-lymphocytes/immunologycomplement/analysis/immunology
831130
M83B0016

Copyright © 1983 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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