Value of lymph node biopsy in unexplained lymphadenopathy in homosexual men. NLM AIDSLINE Important note: Information in this article was accurate in 1983. The state of the art may have changed since the publication date.

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Value of lymph node biopsy in unexplained lymphadenopathy in homosexual men.

JAMA. 1983 Sep 9;250(10):1313-7. Unique Identifier : AIDSLINE MED/83268922
Brynes RK; Chan WC; Spira TJ; Ewing EP Jr; Chandler FW

Abstract: The acquired immune deficiency syndrome (AIDS) manifested by severe opportunistic infections, Kaposi's sarcoma, or lymphoma often has a prodrome of lymphadenopathy accompanied by constitutional symptoms. We studied the histopathologic findings of lymph node biopsy specimens and peripheral blood immunologic parameters of 24 clinically indistinguishable homosexual men with chronic generalized lymphadenopathy. Two different morphological patterns were observed: (1) lymph nodes with follicular and paracortical hyperplasia in 21 patients who had had no clinical deterioration and (2) an atypical pattern of lymphoid proliferation in three patients who experienced rapid development of non-Hodgkin's lymphoma and/or opportunistic infections. Several immunologic laboratory results paralleled these changes. Lymph node morphological findings seem to be a useful predictor of outcome in homosexual men with generalized lymphadenopathy.
Keywords: Acquired Immunodeficiency Syndrome/*DIAGNOSIS Adult Biopsy *Homosexuality Human Hyperplasia Immunoblastic Lymphadenopathy/DIAGNOSIS/IMMUNOLOGY Lymph Nodes/*PATHOLOGY Lymphatic Diseases/*DIAGNOSIS/IMMUNOLOGY Lymphopenia/DIAGNOSIS/IMMUNOLOGY Male Middle Age Pneumonia, Pneumocystis carinii/DIAGNOSIS Sarcoma, Kaposi's/DIAGNOSIS T-Lymphocytes, Helper-Inducer/IMMUNOLOGY T-Lymphocytes, Suppressor-Effector/IMMUNOLOGY JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDdiagnosisadultbiopsyKWDhomosexualityhumanhyperplasiaimmunoblasticlymphadenopathy/diagnosis/immunologylymphnodes/KWDpathologylymphaticdiseases/KWDdiagnosis/immunologylymphopenia/diagnosis/immunologymalemiddleagepneumonia,pneumocystiscarinii/diagnosissarcoma,kaposi's/diagnosist-lymphocytes,helper-inducer/immunologyt-lymphocytes,suppressor-effector/immunologyjournalarticle
831130
M83B0014

Copyright © 1983 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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