The present review is concerned with the main pathophysiological, clinical and therapeutic progresses in the following fields: gastro-esophageal reflux, gastric antisecretory drugs, chronic inflammatory bowel diseases, cancer of colon and esophagus, pancreatic diseases (chronic pancreatitis, pancreatic carcinoma), acu
Generalized, persistent lymphadenopathies were observed in homosexual men and considered a possible prodrome of acquired immune deficiency syndrome (AIDS). To evaluate these lymphadenopathies, 25 lymph node biopsy specimens from homosexual men with lymphadenopathy (18), lymphadenopathy associated with AIDS (five), and
Schroff RW; Gottlieb MS; Prince HE; Chai LL; Fahey JL
Acquired immunodeficiency and Kaposi s sarcoma are epidemic among homosexual men in the United States . We have identified three clinically distinct disease syndromes in homosexually active men: a syndrome of severe cellular immunodeficiency including infection with Pneumocystis carinii
The case of a 44-year-old homosexual man with cryptosporidial enteritis associated with multiple opportunistic infections and increased T-suppressor cells is reported. This case calls attention to cryptosporidia as the cause of unremitting diarrhea in homosexual men with the syndrome of opportunistic infectious diseas
The acquired immune deficiency syndrome (AIDS) represents a new epidemic of major proportions. Risk factors include homosexuality, intravenous drug abuse, Haitian descent, and multiple transfusion in the presence of hemophilia A. The etiology of AIDS remains unknown, but there is increasing evidence implicating a tran
Essex M; McLane MF; Lee TH; Tachibana N; Mullins JI; Kreiss J; Kasper CK; Poon MC; Landay A; Stein SF; Francis DP; Cabradilla C; Lawrence DN; Evatt BL
Along with homosexual men, Haitians, and intravenous drug abusers, hemophiliacs are at high risk of contracting acquired immunodeficiency syndrome (AIDS). An earlier study revealed that 36 percent of a group of the AIDS patients had antibodies to cell membrane antigens associated with the human T-cell leukemia virus (
To identify risk factors for the occurrence of Kaposi s sarcoma and Pneumocystis carinii pneumonia in homosexual men, we conducted a case-control study in New York City, San Francisco, Los Angeles, and Atlanta. Fifty patients (cases) (39 with Kaposi s sarcoma, 8 with pneumocystis pneumonia, and 3 with both) and 120 ma
Ann Intern Med. 1983 Aug;99(2):159-64. Unique Identifier : AIDSLINE MED/83281093
deShazo RD; Andes WA; Nordberg J; Newton J; Daul C; Bozelka B
Recently, hemophiliac patients receiving factor VIII concentrate therapy have developed the acquired immunodeficiency syndrome. Because abnormalities of cell-mediated immunity are found in this syndrome, we evaluated the peripheral blood immunologic status of 24 patients with classic hemophilia and 5 patients with fac
Twenty-one (100%) Haitians and 42 (21.5%) of 192 native black Americans autopsied in a 33-month period at Jackson Memorial Hospital, Miami, were included in this review. All autopsied materials were examined. Among the Haitians autopsied, infectious diseases accounted for 11 (52%) of 21 deaths. Toxoplasma encephalitis
Many homosexual men with the acquired immunodeficiency syndrome (AIDS) have an unusual acid-labile form of human leukocyte, or alpha, interferon in their serum. Male patients with classic hemophilia treated with lyophilized clotting-factor concentrates are also at high risk for the development of AIDS. To determine wh
Blayney DW; Jaffe ES; Blattner WA; Cossman J; Robert-Guroff M; Longo DL; Bunn PA Jr; Gallo RC
The human T-cell leukemia/lymphoma virus (HTLV) is a novel type-C retrovirus isolated from patients with T-lymphoproliferative malignancies. Thirteen cases of HTLV-associated malignancy from US centers were studied in detail. Ten of these cases share common clinical features and define a typical virus-associated adult
Ammann AJ; Abrams D; Conant M; Chudwin D; Cowan M; Volberding P; Lewis B; Casavant C
Homosexual men with Kaposi sarcoma, lymphadenopathy syndrome, opportunistic infection, and nonhomosexual traditional Kaposi sarcoma were evaluated for B cell, T cell, and complement immunity and compared to normal controls and homosexual controls. No significant immunologic abnormalities were found in the traditional
Two patients who contracted acquired immune deficiency syndrome (AIDS) could not be included in any of the known high-risk groups for this syndrome (ie, they were not homosexual, intravenous [IV] drug abusers, Haitian, or hemophiliacs). Patient 1, however, had regular sexual contact with her husband, an IV drug abuser
The acquired immune deficiency syndrome (AIDS) manifested by severe opportunistic infections, Kaposi s sarcoma, or lymphoma often has a prodrome of lymphadenopathy accompanied by constitutional symptoms. We studied the histopathologic findings of lymph node biopsy specimens and peripheral blood immunologic parameters
N Engl J Med. 1983 Aug 25;309(8):453-8. Unique Identifier : AIDSLINE MED/83271352
Lane HC; Masur H; Edgar LC; Whalen G; Rook AH; Fauci AS
We studied B-lymphocyte function in 12 homosexual male patients with the acquired immunodeficiency syndrome, 5 healthy homosexual men, and 12 heterosexual controls. In comparison with the heterosexual controls, the patients were found to have elevated numbers of cells spontaneously secreting immunoglobulin, decreased
No To Shinkei. 1983 Apr;35(4):337-42. Unique Identifier : AIDSLINE MED/83256939
Yabuki S; Kazahaya Y; Ikeda K
A 20-year-old man, a college student, was admitted to Kochi Municipal Central Hospital with a month s history of slurring of speech and unsteadiness of gait. He had developed fever, sore throat and cervical lymphadenopathy. On admission, the throat was mildly injected, and enlarged lymph nodes were palpable in the lat
Pahwa S; Kirkpatrick D; Ching C; Lopez C; Pahwa R; Smithwick E; O'Reilly R; August C; Pasquariello P; Good RA
Cytomegalovirus ( CMV ) was repeatedly isolated from urine and saliva of a 20-month-old male child with recurrent episodes of pneumonia, high fever, rash, lymphadenopathy, oral ulceration, and neutropenia. Immunologic evaluation revealed decreased serum IgG and Ig
Rook AH; Masur H; Lane HC; Frederick W; Kasahara T; Macher AM; Djeu JY; Manischewitz JF; Jackson L; Fauci AS; Quinnan GV Jr
The recently described acquired immune deficiency syndrome (AIDS) is characterized by the occurrence of severe opportunistic infections and an aggressive form of Kaposi s sarcoma. A variety of profound defects in cell-mediated immunity have been reported in association with the AIDS, including deficiencies in natural
Science. 1983 Aug 26;221(4613):867-9. Unique Identifier : AIDSLINE MED/83275728
Kozak CA; Sears JF; Hoggan MD
The mouse homolog (c-sis) of the transforming gene of the simian sarcoma virus was mapped to chromosome 15 by the Southern blot analysis of DNA s from hamster-mouse somatic cell hybrids. Alterations in c-sis expression may thus play a role in the various murine neoplastic diseases characterized by rearrangements or du
Ann Intern Med. 1983 Aug;99(2):151-8. Unique Identifier : AIDSLINE MED/83281092
Rogers MF; Morens DM; Stewart JA; Kaminski RM; Spira TJ; Feorino PM; Larsen SA; Francis DP; Wilson M; Kaufman L
The Centers for Disease Control conducted a case-control study to investigate an outbreak of Kaposi s sarcoma and Pneumocystis carinii pneumonia in homosexual men. The occurrence of these diseases was found to be associated with certain aspects of lifestyle, including a greater number of male sex partners per year, ex
Ann Intern Med. 1983 Aug;99(2):208-20. Unique Identifier : AIDSLINE MED/83281108
Gottlieb MS; Groopman JE; Weinstein WM; Fahey JL; Detels R
Recently, a new epidemic illness, the acquired immunodeficiency syndrome, has dramatically emerged in the United States , Europe, and Haiti . The syndrome represents an unprecedented epidemic form of immunodeficiency involving prominent defects of the
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