Catovsky D; Linch DC; Beverley PC; Royal Postgraduate Medical Sch., Ducane Road, London W12 0HS,; England
A review of clinical and morphological features, cytogenics, and cytochemistry of T cell malignancies, including T acute lymphoblastic leukemia and T lymphoblastic lymphoma, adult T cell lymphoma-leukemia, T-zone lymphoma, T prolymphocytic leukemia, T cell chronic lymphocytic leukemia (T-CLL) and chronic lymphocytosis
Acquired immune deficiency syndrome (AIDS), which has reached epidemic proportions since first detected in 1981, affects primarily homosexual men, iv drug users and their sexual partners, Haitian immigrants, hemophiliacs, and children of high risk parents or AIDS victims. Characterized by a deficiency of helper T cell
The ATP analog 5 -adenylyl imidodiphosphate (AMP-PNP) inhibits transcription of specific genes by the RNA polymerase II contained in whole cell extracts, not only with promoters that contain A as the first nucleotide of the transcript, but also with those that initiate transcripts with G or U. The analog AMP-PNP (a co
Levo Y; Tur-Kaspa R; Shouval D; Brautbar C; Eliakim M
The cause of the HBsAg carrier state is unknown, and environmental genetic and immunologic factors have been implicated. Herein, a family is described in which the carrier state was associated with the HLA-A28BW15 haplotype and with impaired cell mediated immunity. The relevance of the genetic marker in this family is
Proc Natl Acad Sci U S A. 1982 Dec;79(24):7857-61. Unique Identifier : AIDSLINE MED/83117775
Le J; Vilcek J; Saxinger C; Prensky W
Human T-cell hybridomas were established by hybridization of concanavalin A-stimulated human peripheral blood lymphocytes with a 6-thioguanine-resistant mutant cell line, designated SH9, derived by irradiation from a cloned human cutaneous T lymphoma line, Hut102-B2. High levels of interferon (IFN) were demonstrated i
There is little direct evidence that viruses cause inflammatory arthritis in the sense that infectious agents classically cause disease. However, there are several mechanisms by which virus infections could be implicated in the pathogenesis of such disorders. In particular virus infection of lymphocytes could produce
The applicability of the enzyme immunoassay technique to the detection of group and interspecies determinants of C-type retroviral proteins was tested. For this purpose four groups of C-type retroviruses (MuLV, FeLV, SiSV/GaLV, and BaEV/RD114) were assayed for group-specific and interspecies reactivities of their p30
The nucleotide sequences of the Gardner-Arnstein feline sarcoma virus (FeSV) long terminal repeat and the adjacent leader sequences 5 to the viral gag gene were determined. These were compared with homologous portions of Synder-Theilen FeSV and with previously published sequences for Moloney murine sarcoma virus and
Known since 1872, the multifocal angiosarcoma called Kaposi s sarcoma takes different forms in different communities. It develops slowly among the mediterranean populations and Jewish Central Europe and most rapidly among Bantus, in Africa, and white homosexuals. Another aspect of the disease has been described in pat
Science. 1983 Feb 4;219(4584):503-5. Unique Identifier : AIDSLINE GENBANK/J00121
Josephs SF; Dalla-Favera R; Gelmann EP; Gallo RC; Wong-Staal F
The 5 nucleotide sequences of the transforming gene of simian sarcoma virus (v-sis) and its human cellular homolog (c-sis) were compared. A short homology was found between helper virus and cellular DNA sequences at the junction of v-sis and c-sis, which may have had a role in the original recombination event leading
Lancet. 1983 Jan 29;1(8318):213-4. Unique Identifier : AIDSLINE MED/83113903
Ragni MV; Lewis JH; Spero JA; Bontempo FA
The immunological status of two multiply transfused patients with severe haemophilia A and diffuse lymphadenopathy was evaluated. But patients appeared clinically well and denied homosexuality or intravenous drug abuse. Immunological studies revealed depressed cellular immune function with anergy, relative lymphopenia
Lancet. 1983 Feb 19;1(8321):388-90. Unique Identifier : AIDSLINE MED/83114041
Henrickson RV; Maul DH; Osborn KG; Sever JL; Madden DL; Ellingsworth LR; Anderson JH; Lowenstine LJ; Gardner MB
A syndrome closely resembling acquired immunodeficiency syndrome (AIDS) in man has been identified in a group of 64 rhesus monkeys (Macaca mulatta) maintained outdoors at the California Primate Research Center. The syndrome is characterised by generalised lymphadenopathy, severe opportunistic infections including
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