Clinical conferences at The Johns Hopkins Hospital: Kaposi's sarcoma.

Important note: Information in this article was accurate in 1983. The state of the art may have changed since the publication date.

Clinical conferences at The Johns Hopkins Hospital: Kaposi's sarcoma.

Johns Hopkins Med J. 1982 Nov;151(5):222-30. Unique Identifier : AIDSLINE MED/83060488
Hood AF; Farmer ER; Weiss RA

Abstract: Kaposi's sarcoma is a multifocal neoplasm of the reticuloendothelial system which has generated great interest recently because of its association with immunosuppressive therapy and its occurrence within a group of homosexual men. Our case demonstrates a relationship between the discontinuation of immunosuppressive therapy and tumor regression in a renal transplant recipient. The clustering of cases in geographic areas and within ethnic groups implies that both heriditary and environmental factors contribute to the pathogenesis of this tumor. Recently described cases have occurred in a setting of multiple infections and concurrent impairment of cell mediated immunity. This suggests that Kaposi's sarcoma may be a model of chronic antigen stimulation leading to decreased immune responsiveness and subsequent unchecked growth of transformed cells.

Keywords: Adult Africa Aged Azathioprine/ADVERSE EFFECTS Case Report Child Child, Preschool Europe Female Foot Homosexuality Human Immunosuppression/ADVERSE EFFECTS Infant Kidney/TRANSPLANTATION Kidney Transplantation Male Maryland Middle Age Prednisone/ADVERSE EFFECTS Sarcoma, Kaposi's/EPIDEMIOLOGY/ETIOLOGY/*PATHOLOGY JOURNAL ARTICLE

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