Acquired immunodeficiency syndrome in a patient with hemophilia. NLM AIDSLINE Important note: Information in this article was accurate in 1983. The state of the art may have changed since the publication date.

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Acquired immunodeficiency syndrome in a patient with hemophilia.

Ann Intern Med. 1983 Mar;98(3):284-6. Unique Identifier : AIDSLINE MED/83150961
Davis KC; Horsburgh CR Jr; Hasiba U; Schocket AL; Kirkpatrick CH

Abstract: A patient with hemophilia A developed T-cell deficiency characterized by infection with several opportunistic pathogens. Immunologic investigation showed cutaneous anergy, lymphocyte unresponsiveness to mitogens and antigens, an abnormal ratio of T-helper and T-suppressor cells with absolute lymphopenia and elevated IgA. The clinical and immunologic characteristics of this patient fit the recently described syndrome of opportunistic infections or Kaposi's sarcoma in patients with acquired T-cell deficiency; however, this patient does not have any of the associated underlying risk factors such as homosexuality, intravenous drug or amyl nitrite use, or positive serologic tests for syphilis. We conclude that the patient's acquired T-cell deficiency can be explained by exposure to a virus or other transmissible agent during factor VIII transfusions.
Keywords: Acquired Immunodeficiency Syndrome/*ETIOLOGY Candidiasis/ETIOLOGY Case Report Cytomegalovirus Infections/ETIOLOGY Factor VIII/ADMINISTRATION & DOSAGE Hemophilia/*COMPLICATIONS Human Injections, Intravenous Male Middle Age Pneumonia, Pneumocystis carinii/ETIOLOGY Support, U.S. Gov't, P.H.S. JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDetiologycandidiasis/etiologycasereportcytomegalovirusinfections/etiologyfactorviii/administration&dosagehemophilia/KWDcomplicationshumaninjections,intravenousmalemiddleagepneumonia,pneumocystiscarinii/etiologysupport,uKWDsKWDgov't,pKWDhKWDsKWDjournalarticle
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M8360010

Copyright © 1983 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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