Acquired immunodeficiency syndrome with Pneumocystis carinii pneumonia and Mycobacterium avium-intracellulare infection in a previously healthy patient with classic hemophilia. Clinical, immunologic, and virologic findings. NLM AIDSLINE Important note: Information in this article was accurate in 1983. The state of the art may have changed since the publication date.

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Acquired immunodeficiency syndrome with Pneumocystis carinii pneumonia and Mycobacterium avium-intracellulare infection in a previously healthy patient with classic hemophilia. Clinical, immunologic, and virologic findings.

Ann Intern Med. 1983 Mar;98(3):287-90. Unique Identifier : AIDSLINE MED/83150962
Poon MC; Landay A; Prasthofer EF; Stagno S

Abstract: A previously healthy patient with classic hemophilia who was on a home infusion program with factor VIII concentrates developed an acquired immunodeficiency syndrome manifested by a dramatic weight loss (47 kg over 12 months), lassitude, transient thrombocytopenia, and opportunistic infections with Varicella zoster, Pneumocystis carinii, and Mycobacterium avium-intracellulare. The patient was not homosexual and had no history of intravenous drug abuse. Immunologic studies showed a persistent lymphopenia with reversal of helper/suppressor-cytotoxic T-lymphocyte ratios, depression of human natural killer cell function, and in-vitro lymphocyte proliferative responses to mitogens and viral antigens. Serum IgA levels were also elevated. Serum antibodies against cytomegalovirus, herpes simplex viruses 1 and 2, Epstein-Barr virus, Varicella zoster, and hepatitis B virus were shown, suggesting previous infection by these agents. Reactivation of cytomegalovirus infection was suggested by a rising titer of antibodies against cytomegalovirus concurrent with pneumocystis pneumonia, and was confirmed by the growth of this virus in a throat culture 2 months later.
Keywords: Acquired Immunodeficiency Syndrome/*COMPLICATIONS Antibodies, Viral/IMMUNOLOGY Case Report Cytomegalovirus/IMMUNOLOGY Hemophilia/*COMPLICATIONS/IMMUNOLOGY Herpesvirus 3, Human/IMMUNOLOGY Herpesvirus 4, Human/IMMUNOLOGY Human Immunity, Cellular Male Middle Age Mycobacterium avium Mycobacterium Infections/*ETIOLOGY Pneumonia, Pneumocystis carinii/*ETIOLOGY Simplexvirus/IMMUNOLOGY Support, U.S. Gov't, Non-P.H.S. Support, U.S. Gov't, P.H.S. Thrombocytopenia/ETIOLOGY JOURNAL ARTICLE

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Copyright © 1983 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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