Altered distribution of T-lymphocyte subpopulations in children and adolescents with haemophilia. NLM AIDSLINE Important note: Information in this article was accurate in 1983. The state of the art may have changed since the publication date.

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Altered distribution of T-lymphocyte subpopulations in children and adolescents with haemophilia.

Lancet. 1983 Mar 5;1(8323):503-5. Unique Identifier : AIDSLINE MED/83140288
Luban NL; Kelleher JF Jr; Reaman GH

Abstract: Acquired immunodeficiency syndrome (AIDS) is a disease of unknown aetiology characterised by opportunistic infections, unusual malignancies, and aberrations in cellular immunity; lymphopenia and reversal of helper/suppressor T-cell ratios are the most common. In this study the immune function in 25 children and adolescents with haemophilia was assessed. Normal humoral immunity was observed in all patients evaluated. T and B cell numbers and stimulation were within normal limits. However, 5 of the patients had reversed helper/suppressor T-cell ratios similar to, but less pronounced than, the reversed ratio observed in patients with clinical signs of AIDS. These results suggest that patients with haemophilia may be at increased risk of AIDS and that regular investigation of cellular immunity is warranted in these patients.
Keywords: Acquired Immunodeficiency Syndrome/BLOOD/*IMMUNOLOGY Adolescence Adult Age Factors Alanine Aminotransferase/BLOOD Child Child, Preschool Hemophilia/BLOOD/*IMMUNOLOGY Human Immunity, Cellular Leukocyte Count Male Risk T-Lymphocytes, Helper-Inducer/*IMMUNOLOGY/METABOLISM T-Lymphocytes, Suppressor-Effector/*IMMUNOLOGY/METABOLISM JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/blood/KWDimmunologyadolescenceadultagefactorsalanineaminotransferase/bloodchildchild,preschoolhemophilia/blood/KWDimmunologyhumanimmunity,cellularleukocytecountmaleriskt-lymphocytes,helper-inducer/KWDimmunology/metabolismt-lymphocytes,suppressor-effector/KWDimmunology/metabolismjournalarticle
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M8360005

Copyright © 1983 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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