Chemotherapy in advanced Kaposi's sarcoma. Implications for current cases in homosexual men. NLM AIDSLINE Important note: Information in this article was accurate in 1983. The state of the art may have changed since the publication date.

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Chemotherapy in advanced Kaposi's sarcoma. Implications for current cases in homosexual men.

Am J Med. 1983 Apr;74(4):652-6. Unique Identifier : AIDSLINE MED/83175695
Volberding P; Conant MA; Stricker RB; Lewis BJ

Abstract: Kaposi's sarcoma has recently appeared in an aggressive form in young, previously healthy, homosexual men. The disease in these patients corresponds most closely to disseminated Kaposi's sarcoma common in areas of Africa. This and the underlying acquired immune deficiency in the current patients in the United States affect the choice of appropriate therapy. Because Kaposi's sarcoma in these patients is rapidly progressive, it often requires aggressive systemic therapy, but this can be difficult given the patients' susceptibility to opportunistic infections. Reports from Africa suggest that Kaposi's sarcoma is very responsive to several chemotherapeutic agents, but these data must be interpreted cautiously because of problems in study design and differences between cases in Africa and the United States. This report reviews the clinical classification of Kaposi's sarcoma and the reported results of chemotherapy in patients with advanced disease. Implications of this experience in the treatment of recent cases in the United States are discussed.
Keywords: Acquired Immunodeficiency Syndrome Acute Disease Africa Antineoplastic Agents/*ADMINISTRATION & DOSAGE Drug Therapy, Combination *Homosexuality Human Male Prognosis Sarcoma, Kaposi's/*DRUG THERAPY/PATHOLOGY Support, Non-U.S. Gov't United States JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndromeacutediseaseafricaantineoplasticagents/KWDadministration&dosagedrugtherapy,combinationKWDhomosexualityhumanmaleprognosissarcoma,kaposi's/KWDdrugtherapy/pathologysupport,non-uKWDsKWDgov'tunitedstatesjournalarticle
830730
M8370034

Copyright © 1983 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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