Graft-vs.-host-associated immune suppression is activated by recognition of allogeneic murine I-A antigens. NLM AIDSLINE Important note: Information in this article was accurate in 1983. The state of the art may have changed since the publication date.

Click here to return to AIDSLINE main menu
DonateNow
Print this Article


Graft-vs.-host-associated immune suppression is activated by recognition of allogeneic murine I-A antigens.

J Exp Med. 1983 Mar 1;157(3):936-46. Unique Identifier : AIDSLINE MED/83162998
Shearer GM; Levy RB

Abstract: Several combinations of F1 hybrid mice were injected intravenously with parental spleen cells to determine the minimal H-2 differences between F1 and parent that are necessary to induce graft-vs.-host-associated immune suppression (GVH-associated suppression). 7-14 d after injection, the spleens of the F1 mice were tested for cytotoxic T lymphocyte potential by in vitro sensitization against trinitrophenyl-self and H-2 alloantigens. The results indicate that parental T lymphocytes must recognize I-A allogeneic determinants of the F1 recipient in order to induce suppression. Recognition of K or D alone or D with I region products other than I-A did not induce suppression. The recognition of I region without K and/or D and even the I-A difference between C57BL/6 and the B6.Cbm12 mutation resulted in immune suppression that was as potent as that resulting from the recognition of K, D, and I together. The possible significance of this function for I-A antigens is discussed with respect to three clinical examples of immune suppression for which this phenomenon may be relevant.
Keywords: Acquired Immunodeficiency Syndrome/ETIOLOGY/IMMUNOLOGY Animal Chromosome Mapping Crosses, Genetic *Genes, MHC Class II *Graft vs Host Reaction H-2 Antigens/GENETICS/IMMUNOLOGY Human *Immune Tolerance Male Mice Mice, Inbred C57BL Mice, Mutant Strains T-Lymphocytes, Cytotoxic/*IMMUNOLOGY JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/etiology/immunologyanimalchromosomemappingcrosses,geneticKWDgenes,mhcclassiiKWDgraftvshostreactionh-2antigens/genetics/immunologyhumanKWDimmunetolerancemalemicemice,inbredc57blmice,mutantstrainst-lymphocytes,cytotoxic/KWDimmunologyjournalarticle
830730
M8370028

Copyright © 1983 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1983. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1983. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .