The effect of hexadimethrine bromide (polybrene) on the infection of the primate retroviruses SSV 1/SSAV 1 and BaEV. NLM AIDSLINE Important note: Information in this article was accurate in 1983. The state of the art may have changed since the publication date.

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The effect of hexadimethrine bromide (polybrene) on the infection of the primate retroviruses SSV 1/SSAV 1 and BaEV.

Arch Virol. 1983;75(4):307-11. Unique Identifier : AIDSLINE MED/83177547
Coelen RJ; Jose DG; May JT

Abstract: Polybrene was shown to enhance the adsorption of simian sarcoma virus-simian sarcoma associated virus complex (SSV-1/SSAV-1) and baboon endogenous virus (BaEV) onto cells in culture. A 16- to 18-fold increased adsorption of both viruses occurred at 8 micrograms/ml polybrene within one hour after infection. The polybrene mediated adsorption was found to be inhibited by the addition of tri-sodium citrate to the culture medium, suggesting the involvement of electrostatic forces. This contention was further supported by the demonstration of temperature independence of the polybrene mediated interaction.
Keywords: Adsorption Citrates/PHARMACOLOGY Dose-Response Relationship, Drug Hexadimethrine/*PHARMACOLOGY Polyamines/*PHARMACOLOGY Retroviridae/*DRUG EFFECTS/PHYSIOLOGY Sarcoma Viruses, Simian/DRUG EFFECTS/PHYSIOLOGY Satellite Viruses/DRUG EFFECTS/PHYSIOLOGY Support, Non-U.S. Gov't Temperature JOURNAL ARTICLE

KWDadsorptioncitrates/pharmacologydose-responserelationship,drughexadimethrine/KWDpharmacologypolyamines/KWDpharmacologyretroviridae/KWDdrugeffects/physiologysarcomaviruses,simian/drugeffects/physiologysatelliteviruses/drugeffects/physiologysupport,non-uKWDsKWDgov'ttemperaturejournalarticle
830730
M8370018

Copyright © 1983 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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