Acquired immunodeficiency in an infant: possible transmission by means of blood products.

Important note: Information in this article was accurate in 1983. The state of the art may have changed since the publication date.

Acquired immunodeficiency in an infant: possible transmission by means of blood products.

Lancet. 1983 Apr 30;1(8331):956-8. Unique Identifier : AIDSLINE MED/83166123
Ammann AJ; Cowan MJ; Wara DW; Weintrub P; Dritz S; Goldman H; Perkins HA

Abstract: An infant who received multiple transfusions during the first few days of life for rhesus disease became ill with recurrent infections when 6 months old. Hepatitis, thrush, Candida dermatitis, otitis media, and disseminated Mycobacterium avium intracellulare infection occurred by 14 months of age. Immunological studies showed raised immunoglobulin levels, decreased mononuclear-cell responses to allogeneic cells and mitogen, and a decreased helper/suppressor cell ratio. It was determined that one of the blood donors, who was well at the time of blood donation, had died 17 months after with multiple opportunistic infections and acquired immunodeficiency. The clinical and laboratory findings in our patient suggest that he acquired a transmissible infectious agent from a blood transfusion, resulting in acquired immunodeficiency, and that this agent was not cytomegalovirus, Epstein-Barr virus, or hepatitis B virus.

Keywords: Acquired Immunodeficiency Syndrome/*ETIOLOGY/TRANSMISSION Blood Platelets/TRANSPLANTATION Blood Transfusion/*ADVERSE EFFECTS Bone Marrow/MICROBIOLOGY Case Report Exchange Transfusion, Whole Blood/ADVERSE EFFECTS Human Infant Infant, Newborn Jaundice, Neonatal/THERAPY Male Mycobacterium avium/ISOLATION & PURIF Mycobacterium Infections/TRANSMISSION Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. JOURNAL ARTICLE

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