Defective B cell function in systemic lupus erythematosus. NLM AIDSLINE Important note: Information in this article was accurate in 1983. The state of the art may have changed since the publication date.

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Defective B cell function in systemic lupus erythematosus.

Clin Exp Immunol. 1982 Jun;48(3):513-8. Unique Identifier : AIDSLINE MED/83002375
Pelton BK; Denman AM

Abstract: The in vitro synthesis of specific anti-influenza virus antibody was measured in cultures of peripheral blood lymphocytes from 25 patients with systemic lupus erythematosus (SLE) and 23 control subjects. Whilst all cultures derived from normal individuals synthesized specific antibody, cultures from patients with SLE were consistently unable to produce anti-influenza antibody. This defect could not be corrected by manipulating the culture conditions or by in vivo immunization. Co-cultivation of separated SLE-B or control B cells, with SLE-T or control T cells showed that the immunodeficiency exhibited by the SLE peripheral blood lymphocytes resides in the B cells.
Keywords: Antibodies, Viral/BIOSYNTHESIS Antibody Specificity Antigens, Viral/IMMUNOLOGY B-Lymphocytes/*IMMUNOLOGY Cell Survival Cells, Cultured Female Human IgG/BIOSYNTHESIS Lupus Erythematosus, Systemic/*IMMUNOLOGY Male Orthomyxoviridae/IMMUNOLOGY JOURNAL ARTICLE

KWDantibodies,viral/biosynthesisantibodyspecificityantigens,viral/immunologyb-lymphocytes/KWDimmunologycellsurvivalcells,culturedfemalehumanigg/biosynthesislupuserythematosus,systemic/KWDimmunologymaleorthomyxoviridae/immunologyjournalarticle
830130
M8310014

Copyright © 1983 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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