Mycobacterium avium-intracellulare: a cause of disseminated life-threatening infection in homosexuals and drug abusers. NLM AIDSLINE Important note: Information in this article was accurate in 1983. The state of the art may have changed since the publication date.

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Mycobacterium avium-intracellulare: a cause of disseminated life-threatening infection in homosexuals and drug abusers.

Ann Intern Med. 1982 Oct;97(4):539-46. Unique Identifier : AIDSLINE MED/83020789
Greene JB; Sidhu GS; Lewin S; Levine JF; Masur H; Simberkoff MS; Nicholas P; Good RC; Zolla-Pazner SB; Pollock AA; Tapper ML; Holzman RS

Abstract: Five men developed disseminated infection with Mycobacterium avium-intracellulare. These patients all lived in the New York City area and presented with their illnesses between January 1981 and September 1981; four were homosexual and one was an intravenous drug abuser. Four patients died. All five patients had defects in the cell-mediated immune response. The infections were characterized histopathologically by poor or absent granulomatous tissue reaction. Clinical isolates of M. avium-intracellulare from all five patients agglutinated commonly used antimycobacterial drugs. The spectrum of opportunistic infections among populations of homosexuals and drug abusers should be expanded to include disseminated disease due to M. avium-intracellulare.
Keywords: Adult Antitubercular Agents/THERAPEUTIC USE Case Report Cytomegalovirus Infections/IMMUNOLOGY Herpes Simplex/IMMUNOLOGY *Homosexuality Human Immunity, Cellular Immunologic Deficiency Syndromes/*IMMUNOLOGY Male Mycobacterium avium/ISOLATION & PURIF Mycobacterium Infections/DRUG THERAPY/*IMMUNOLOGY New York City Pneumonia, Pneumocystis carinii/IMMUNOLOGY *Substance Abuse Syndrome JOURNAL ARTICLE

KWDadultantitubercularagents/therapeuticusecasereportcytomegalovirusinfections/immunologyherpessimplex/immunologyKWDhomosexualityhumanimmunity,cellularimmunologicdeficiencysyndromes/KWDimmunologymalemycobacteriumavium/isolation&purifmycobacteriuminfections/drugtherapy/KWDimmunologynewyorkcitypneumonia,pneumocystiscarinii/immunologyKWDsubstanceabusesyndromejournalarticle
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Copyright © 1983 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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