Chromosomal localization of the human homolog (c-sis) of the simian sarcoma virus onc gene. NLM AIDSLINE Important note: Information in this article was accurate in 1983. The state of the art may have changed since the publication date.

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Chromosomal localization of the human homolog (c-sis) of the simian sarcoma virus onc gene.

Science. 1982 Nov 12;218(4573):686-8. Unique Identifier : AIDSLINE MED/83041283
Dalla-Favera R; Gallo RC; Giallongo A; Croce CM

Abstract: Nonrandom chromosome rearrangements of chromosome 22 have been identified in different human malignancies. As a result of Southern blot hybridization of a c-sis probe to DNA's from mouse-human somatic cell hybrids, the human homolog (c-sis) of the transforming gene of simian sarcoma virus was assigned to chromosome 22. Hybrids between thymidine kinase-deficient mouse cells and human fibroblasts carrying a translocation of the region q11-qter of chromosome 22 to chromosome 17 were also analyzed. These studies demonstrate that the human c-sis gene is on region 22q11 greater than qter.
Keywords: *Cell Transformation, Viral Chromosome Mapping *Chromosomes, Human, 21-22 Genes, Structural Human *Oncogenes Retroviridae/*GENETICS Sarcoma Viruses, Simian/*GENETICS Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. JOURNAL ARTICLE

KWDcelltransformation,viralchromosomemappingKWDchromosomes,human,21-22genes,structuralhumanKWDoncogenesretroviridae/KWDgeneticssarcomaviruses,simian/KWDgeneticssupport,non-uKWDsKWDgov'tsupport,uKWDsKWDgov't,pKWDhKWDsKWDjournalarticle
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Copyright © 1983 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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