Natural resistance to parental T-lymphocyte-induced immunosuppression in F1 hybrid mice: implications for acquired immune deficiency syndrome (AIDS). NLM AIDSLINE Important note: Information in this article was accurate in 1983. The state of the art may have changed since the publication date.

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Natural resistance to parental T-lymphocyte-induced immunosuppression in F1 hybrid mice: implications for acquired immune deficiency syndrome (AIDS).

Immunol Rev. 1983;73:115-26. Unique Identifier : AIDSLINE MED/83289387
Shearer GM

Abstract: The classical laws of transplantation which state that the major transplantation antigens are co-dominantly expressed do not account for the experimental observations that F1 hybrid mice can be genetically resistant to the growth of transplanted parental hemopoietic cells. Similarly, F1 mice can also be resistant to parental T-lymphocyte-induced immune suppression. The two phenomena are similar in that both: (a) mature relatively late in ontogeny; (b) can be over-ridden or saturated by excessive numbers of cells; and (c) the F1 host appears to recognize homozygous H-2Db of the donor. They differ in that many more cells appear to be required to over-ride resistance to immune suppression than to saturate resistance to bone-marrow grafts. The findings that natural resistance can be demonstrated for T-lymphocyte suppression of immune potential is discussed with respect to the synergistic effects of graft-versus-host disease and infection and the possible role of such resistance in susceptibility to acquired immune deficiency syndrome.
Keywords: Acquired Immunodeficiency Syndrome/*IMMUNOLOGY Animal Comparative Study Graft vs Host Reaction Histocompatibility Human Hybridization *Immune Tolerance *Immunity, Natural Mice Mice, Inbred Strains T-Lymphocytes/*IMMUNOLOGY/TRANSPLANTATION T-Lymphocytes, Cytotoxic/IMMUNOLOGY Transplantation, Homologous JOURNAL ARTICLE REVIEW

KWDacquiredimmunodeficiencysyndrome/KWDimmunologyanimalcomparativestudygraftvshostreactionhistocompatibilityhumanhybridizationKWDimmunetoleranceKWDimmunity,naturalmicemice,inbredstrainst-lymphocytes/KWDimmunology/transplantationt-lymphocytes,cytotoxic/immunologytransplantation,homologousjournalarticlereview
831230
M83C0042

Copyright © 1983 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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