Demonstration of serum antibodies to Cryptosporidium sp. in normal and immunodeficient humans with confirmed infections. NLM AIDSLINE Important note: Information in this article was accurate in 1983. The state of the art may have changed since the publication date.

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Demonstration of serum antibodies to Cryptosporidium sp. in normal and immunodeficient humans with confirmed infections.

J Clin Microbiol. 1983 Jul;18(1):165-9. Unique Identifier : AIDSLINE MED/83291481
Campbell PN; Current WL

Abstract: Antibodies to Cryptosporidium sp. were detected in sera from 12 immunocompetent individuals recovered from cryptosporidiosis and from 5 subjects with an acquired immunodeficiency syndrome and persistent cryptosporidiosis by an indirect immunofluorescent (IIF) test. Marked seroconversion accompanied recovery from infection in immunocompetent individuals, and their IIF titers remained high (1:40 to 1:640) for at least 1 year. No antibodies to Cryptosporidium sp. were detected in sera from two subjects with hypogammaglobulinemia, normal T-cell function, and persistent cryptosporidiosis or in sera from individuals not previously exposed to Cryptosporidium sp. Very little or no cross-reactivity with the other coccidia--Toxoplasma, Sarcocystis, and Isospora spp.--occurred in the IIF test procedure. The application of this IIF procedure, along with recently developed techniques to detect oocysts in the feces, should provide the basis for a more accurate assessment of the number of individuals within any subject group with previous and active Cryptosporidium infections.
Keywords: Acquired Immunodeficiency Syndrome/*IMMUNOLOGY Agammaglobulinemia/*IMMUNOLOGY Antibodies/*ANALYSIS Coccidiosis/*IMMUNOLOGY Fluorescent Antibody Technique Human Species Specificity Support, Non-U.S. Gov't Support, U.S. Gov't, Non-P.H.S. JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDimmunologyagammaglobulinemia/KWDimmunologyantibodies/KWDanalysiscoccidiosis/KWDimmunologyfluorescentantibodytechniquehumanspeciesspecificitysupport,non-uKWDsKWDgov'tsupport,uKWDsKWDgov't,non-pKWDhKWDsKWDjournalarticle
831230
M83C0041

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