Mononuclear phagocytes in the newborn: their relation to the state of relative immunodeficiency. NLM AIDSLINE Important note: Information in this article was accurate in 1983. The state of the art may have changed since the publication date.

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Mononuclear phagocytes in the newborn: their relation to the state of relative immunodeficiency.

Am J Pediatr Hematol Oncol. 1983 Summer;5(2):189-98. Unique Identifier : AIDSLINE MED/83306424
Mills EL

Abstract: The neonatal period is a state of relative immunodeficiency during which newborns are particularly vulnerable to bacterial, protozoal, and viral infections. In addition, they localize infection poorly, mount a sluggish antibody response to injected antigens and are relatively anergic. Both in vivo and in vitro studies suggest that functional immaturity of neonatal macrophages may contribute to this immunologic hyporesponsiveness. Resistance to viral and bacterial infection and production of antibody can be enhanced in neonates by injection of adult macrophages. Specific functional defeats in newborns' monocytes have been demonstrated in their capacity to chemotax, to resist intracellular multiplication of virus and to effect antibody-dependent cell-mediated cytotoxicity towards virus-infected target cells. Monocytes from newborns also appear to present antigen poorly, and to co-operate with T-lymphocytes in the suppression of IgG-production by B cells.
Keywords: Antibody Formation Antibody-Dependent Cell Cytotoxicity Blood Bactericidal Activity Chemotaxis Herpes Simplex/IMMUNOLOGY Human Immune Adherence Reaction *Immunocompetence *Infant, Newborn Infant, Newborn, Diseases/IMMUNOLOGY Listeria Infections/IMMUNOLOGY Macrophages/*IMMUNOLOGY Monocytes/*IMMUNOLOGY Oxygen Consumption Phagocytosis JOURNAL ARTICLE REVIEW

KWDantibodyformationantibody-dependentcellcytotoxicitybloodbactericidalactivitychemotaxisherpessimplex/immunologyhumanimmuneadherencereactionKWDimmunocompetenceKWDinfant,newborninfant,newborn,diseases/immunologylisteriainfections/immunologymacrophages/KWDimmunologymonocytes/KWDimmunologyoxygenconsumptionphagocytosisjournalarticlereview
831230
M83C0037

Copyright © 1983 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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