Oncological consequences of impaired immune surveillance against ubiquitous viruses. NLM AIDSLINE Important note: Information in this article was accurate in 1983. The state of the art may have changed since the publication date.

Click here to return to AIDSLINE main menu
DonateNow
Print this Article


Oncological consequences of impaired immune surveillance against ubiquitous viruses.

J Clin Immunol. 1983 Jul;3(3):197-206. Unique Identifier : AIDSLINE MED/83291438
Purtilo DT; Linder J

Abstract: The immune system is constantly challenged by ubiquitous viruses. Multiple immune defenses have evolved to meet these challenges, and thus immunocompetent individuals successfully respond to infection without sequela. X-linked lymphoproliferative syndrome patients, renal allograft recipients, and acquired immunodeficiency syndrome patients share impaired immune surveillance as a common feature. Such individuals are variously susceptible to numerous untoward complications following infection with Epstein-Barr virus, cytomegalovirus, herpes simplex virus, human papillomavirus, and hepatitis B virus. We hypothesize that failure of the immune system to control these viruses is instrumental in the occurrence of some B-cell lymphomas. Kaposi's sarcoma, and squamous-cell and hepatocellular carcinomas. Herein we review some mechanisms responsible for the breakdown of immune surveillance and the permissive role immunodeficiency plays in viral oncogenesis.
Keywords: Acquired Immunodeficiency Syndrome/ETIOLOGY/IMMUNOLOGY/ MICROBIOLOGY Adolescence Adult Aged Cell Transformation, Neoplastic/*IMMUNOLOGY *Cell Transformation, Viral Cytomegalovirus Infections/IMMUNOLOGY Female Herpesvirus 4, Human/IMMUNOLOGY Human *Immunity, Cellular *Immunologic Surveillance Kidney/TRANSPLANTATION Kidney Transplantation Lymphoproliferative Disorders/IMMUNOLOGY Male Middle Age Neoplasms/IMMUNOLOGY Sex Chromosome Abnormalities Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. X Chromosome JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/etiology/immunology/microbiologyadolescenceadultagedcelltransformation,neoplastic/KWDimmunologyKWDcelltransformation,viralcytomegalovirusinfections/immunologyfemaleherpesvirus4,human/immunologyhumanKWDimmunity,cellularKWDimmunologicsurveillancekidney/transplantationkidneytransplantationlymphoproliferativedisorders/immunologymalemiddleageneoplasms/immunologysexchromosomeabnormalitiessupport,non-uKWDsKWDgov'tsupport,uKWDsKWDgov't,pKWDhKWDsKWDxchromosomejournalarticle
831230
M83C0023

Copyright © 1983 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1983. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1983. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .