Expression of a platelet-derived growth factor-like protein in simian sarcoma virus transformed cells. NLM AIDSLINE Important note: Information in this article was accurate in 1983. The state of the art may have changed since the publication date.

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Expression of a platelet-derived growth factor-like protein in simian sarcoma virus transformed cells.

Science. 1983 Sep 30;221(4618):1348-50. Unique Identifier : AIDSLINE MED/83302086
Deuel TF; Huang JS; Huang SS; Stroobant P; Waterfield MD

Abstract: The near identity of the partial amino acid sequence of human platelet-derived growth factor (PDGF) and that predicted for p28sis, the putative transforming protein of the simian sarcoma virus (SSV), suggests expression of a growth factor activity may be central for transformation by SSV. It is now reported that SSV-transformed cells but not control cells contain a growth factor activity that is identical to PDGF in immunoassay, in mitogenic dose response, and in specific mitogenic activity. The protein immunoprecipitated by antiserum to human PDGF has an apparent molecular weight of 20,000, identical to that of p20sis, the putative intracellular degradation product of p28sis. The results support the concept that expression of a PDGF-like molecule, which appears to be the product of the viral-sis gene, is responsible for the abnormal regulation of growth is SSV-transformed cells.
Keywords: Amino Acid Sequence Animal *Cell Transformation, Viral Cross Reactions DNA Replication/DRUG EFFECTS *Genes, Viral Growth Substances/*GENETICS/IMMUNOLOGY Mice Molecular Weight Peptides/*GENETICS/IMMUNOLOGY Retroviridae/*GENETICS Sarcoma Viruses, Simian/*GENETICS Sarcoma, Experimental/*PHYSIOPATHOLOGY JOURNAL ARTICLE

KWDaminoacidsequenceanimalKWDcelltransformation,viralcrossreactionsdnareplication/drugeffectsKWDgenes,viralgrowthsubstances/KWDgenetics/immunologymicemolecularweightpeptides/KWDgenetics/immunologyretroviridae/KWDgeneticssarcomaviruses,simian/KWDgeneticssarcoma,experimental/KWDphysiopathologyjournalarticle
831230
M83C0017

Copyright © 1983 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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