Immunohistologic detection of antigen related to primate type C retrovirus p30 in normal human placentas. NLM AIDSLINE Important note: Information in this article was accurate in 1983. The state of the art may have changed since the publication date.

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Immunohistologic detection of antigen related to primate type C retrovirus p30 in normal human placentas.

Am J Pathol. 1983 Sep;112(3):347-56. Unique Identifier : AIDSLINE MED/83306039
Maeda S; Mellors RC; Mellors JW; Jerabek LB; Zervoudakis IA

Abstract: This study reports the immunohistologic detection of SSAV/GaLV type C retrovirus p30-related antigen in unfixed cryostat sections of normal human term placentas by the indirect immunofluorescence method. Goat anti-SSAV p28 serum reacted specifically with 10 of 10 anatomic specimens of human placenta. Goat anti-GaLV p29 serum reacted similarly with 8 of 10 specimens. Goat anti-BaEV p28, anti-RD-114 p28, anti-FeLV p27, anti-R-MuLV p30, and anti-MPMV p27 gave no specific reaction with placenta. The anti-SSAV p28 and anti-GaLV p29 reactive antigen was located in the placenta mainly at the basal aspect of syncytiotrophoblast near the underlying trophoblastic basement membrane where type C retroviruslike particles have been found electronmicroscopically. The specific antibody activity of anti-SSAV p28 serum against placenta was removed by critical absorption with disrupted SSAV or GaLV but not RD-114 or MuLV. These results suggest the presence in human placenta of a putative type C retroviral protein which cross-reacts with the p30 protein of the SSAV/GaLV type C retrovirus group.
Keywords: Animal Antigen-Antibody Reactions Antigens, Viral/*ANALYSIS/IMMUNOLOGY Buffers Chorionic Villi/IMMUNOLOGY Female Fluorescent Antibody Technique Gonadotropins, Chorionic/IMMUNOLOGY Human Hydrochloric Acid/PHARMACOLOGY Immune Sera/PHARMACOLOGY Placenta/*IMMUNOLOGY Pregnancy Sarcoma Viruses, Simian/IMMUNOLOGY Sarcoma, Experimental/*IMMUNOLOGY Support, U.S. Gov't, P.H.S. Viral Proteins/*IMMUNOLOGY JOURNAL ARTICLE

KWDanimalantigen-antibodyreactionsantigens,viral/KWDanalysis/immunologybufferschorionicvilli/immunologyfemalefluorescentantibodytechniquegonadotropins,chorionic/immunologyhumanhydrochloricacid/pharmacologyimmunesera/pharmacologyplacenta/KWDimmunologypregnancysarcomaviruses,simian/immunologysarcoma,experimental/KWDimmunologysupport,uKWDsKWDgov't,pKWDhKWDsKWDviralproteins/KWDimmunologyjournalarticle
831230
M83C0015

Copyright © 1983 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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