Antibodies to human T cell leukaemia virus-associated membrane antigens in haemophiliacs: evidence for infection before 1980.

Important note: Information in this article was accurate in 1983. The state of the art may have changed since the publication date.

Antibodies to human T cell leukaemia virus-associated membrane antigens in haemophiliacs: evidence for infection before 1980.

Lancet. 1983 Sep 24;2(8352):698-700. Unique Identifier : AIDSLINE MED/83296471
Evatt BL; Stein SF; Francis DP; Lawrence DN; McLane MF; McDougal JS; Lee TH; Spira TJ; Cabradilla C; Mullens JI; Essex M

Abstract: Human T cell leukaemia virus (HTLV), HTLV proviral DNA, and antibodies to HTLV or a related agent have recently been detected in patients with acquired immunodeficiency syndrome (AIDS). Antibodies against HTLV-related antigens were assayed by means of indirect living cell immunofluorescence of HTLV-infected cells in sera recently collected from Georgia haemophiliacs and in sera collected between 1976 and 1981 from New York haemophiliacs. 5 of 45 Georgia haemophiliacs and 8 of 48 New York haemophiliacs had antibodies to HTLV-associated cell membrane antigen (HTLV-MA). None of the control Georgia patients on haemodialysis or with chronic hepatitis had detectable antibodies. The 5 haemophiliac patients from Georgia with HTLV-MA had significantly fewer T4 lymphocytes than similar HTLV-MA-negative patients. There were no other significant immunological differences between these groups. These data suggest that transfusions with blood products may expose haemophiliacs to a substantial risk of acquiring HTLV or a related virus.

Keywords: Acquired Immunodeficiency Syndrome/IMMUNOLOGY Adolescence Adult Animal Antibodies, Viral/*ANALYSIS Antigens, Surface/*IMMUNOLOGY Antigens, Viral/IMMUNOLOGY Blood Transfusion/ADVERSE EFFECTS Comparative Study Factor VIII/ADMINISTRATION & DOSAGE Fluorescent Antibody Technique Georgia Hemophilia/COMPLICATIONS/*IMMUNOLOGY Human Leukocyte Count Male Middle Age New York City Retroviridae/*IMMUNOLOGY Risk T-Lymphocytes/CYTOLOGY/IMMUNOLOGY Tumor Virus Infections/DIAGNOSIS/*TRANSMISSION JOURNAL ARTICLE

831230
M83C0004

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1983. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1983. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .