Current epidemiologic data suggest that a possible infectious and contagious microbial agent is responsible for the recent outbreak of Kaposi s sarcoma and the acquired immunodeficiency syndrome affecting young homosexual men. In this histopathologic study, rare foci of acid-fast, and Giemsa-stained coccoid forms, and
In the period October 10, 1980, to January 19, 1981, 83 cases of rash illness compatible with rubella were reported in Sanford, ME. Twenty-two (27%) were confirmed serologically. Forty cases (48%) occurred in Sanford High School students; the overall attack rate was 3.2%. A case-control study was undertaken to determi
A case of maternal death due to Listeria monocytogenes bacteremia, with survival of the prematurely delivered infant, is presented. Lymphopenia and a Haitian origin suggest that the fatal outcome was related to the acquired immunodeficiency syndrome (AIDS). To our knowledge, this is the first recorded instance of a ma
Horowitz SL; Bentson JR; Benson F; Davos I; Pressman B; Gottlieb MS
Several distinct patterns of neurological involvement occur in epidemic acquired immune deficiency syndrome (AIDS). Two patients with this disorder had Toxoplasma gondii encephalitis, one suspected and one proved. Computed tomographic (CT) scanning showed focal lesions in both patients. Spinal fluids were remarkable f
Between June 1981 and February 1983, the Centers for Disease Control (Atlanta) received reports of 1,000 patients living in the United States who met a surveillance definition for the acquired immune deficiency syndrome (AIDS). Seventy-three percent of these patients were diagnosed aft
During the last two years a new syndrome has been recognized which involves a severe acquired cellular immunodeficiency. More than 1300 cases have already been identified, mainly in the United States . Clinically the patients present with opportunistic infections, especially Pneumocysti
The classical laws of transplantation which state that the major transplantation antigens are co-dominantly expressed do not account for the experimental observations that F1 hybrid mice can be genetically resistant to the growth of transplanted parental hemopoietic cells. Similarly, F1 mice can also be resistant to p
Antibodies to Cryptosporidium sp. were detected in sera from 12 immunocompetent individuals recovered from cryptosporidiosis and from 5 subjects with an acquired immunodeficiency syndrome and persistent cryptosporidiosis by an indirect immunofluorescent (IIF) test. Marked seroconversion accompanied recovery from infec
Due to increasing numbers of patients with documented infections with Cryptosporidium and other coccidia, it is important for the physician and clinical laboratory to be aware of the appropriate diagnostic techniques necessary for organism recovery and identification. Although Cryptosporidium is found in the gastroint
The neonatal period is a state of relative immunodeficiency during which newborns are particularly vulnerable to bacterial, protozoal, and viral infections. In addition, they localize infection poorly, mount a sluggish antibody response to injected antigens and are relatively anergic. Both in vivo and in vitro studies
Ann Allergy. 1983 Sep;51(3):351-61. Unique Identifier : AIDSLINE MED/83306741
Daul CB; deShazo RD
It is clear that there is a distinct new clinical entity of acquired immune deficiency which manifests itself by opportunistic infections and KS. It occurs in selected groups of the population but with an ever increasing spectrum. The clinical presentation is extremely varied and the spectrum of disease runs a wide ga
Although there is no epidemiologic evidence for increased spread of the disease to non-high-risk groups, many investigators speculate that AIDS may be caused by an infectious agent that can be transmitted through blood or blood products. If this hypothesis proves to be correct, dramatic public measures will have to be
Public Health Rep. 1983 Jul-Aug;98(4):320-3. Unique Identifier : AIDSLINE MED/83300800
Meyer HM Jr
Rarely has a public health issue emerged that has had impact on so many aspects of the responsibilities of the Food and Drug Administration. In a curious sense, the emergence of AIDS as a national problem has been timely. Only a few years ago, the scientific basis did not exist for performing studies of the immunology
The productive infection and transformation of fresh human lymphocytes by several HTLV isolates have recently been reported. We extend these observations here with the description of multiple immortalized, non-producer, human umbilical cord blood lymphocyte cultures developed by cocultivation or fusion of fresh cells
Cortical gray matter extracts of patients with Huntington s disease (HD) were investigated for their antigenic properties with serum from both HD patients and normal controls. Both patient and control sera appeared to precipitate two closely migrating proteins of MW 14.4K and 15K, which could be found in normal brain
The immune system is constantly challenged by ubiquitous viruses. Multiple immune defenses have evolved to meet these challenges, and thus immunocompetent individuals successfully respond to infection without sequela. X-linked lymphoproliferative syndrome patients, renal allograft recipients, and acquired immunodefici
DNAs obtained from bone marrow cells of 31 children with neoplasms of mesenchymal origin were tested for the presence of proviral simian sarcoma associated virus by southern blot-hybridization. The lower limit of detection in this method was one provirus per 20-30 cells. Applying stringent conditions of hybridization,
The observation by Epstein and Barr (EB) of virus particles in Burkitt lymphoma cells in 1964 led 4 years later to the discovery that this virus was the long sought agent responsible for infectious mononucleosis. Pathophysiologically the EB virus specifically infects B lymphocytes of the immune system and induces perp
The near identity of the partial amino acid sequence of human platelet-derived growth factor (PDGF) and that predicted for p28sis, the putative transforming protein of the simian sarcoma virus (SSV), suggests expression of a growth factor activity may be central for transformation by SSV. It is now reported that SSV-t
Am J Pathol. 1983 Sep;112(3):347-56. Unique Identifier : AIDSLINE MED/83306039
Maeda S; Mellors RC; Mellors JW; Jerabek LB; Zervoudakis IA
This study reports the immunohistologic detection of SSAV/GaLV type C retrovirus p30-related antigen in unfixed cryostat sections of normal human term placentas by the indirect immunofluorescence method. Goat anti-SSAV p28 serum reacted specifically with 10 of 10 anatomic specimens of human placenta. Goat anti-GaLV p2
Am J Pathol. 1983 Sep;112(3):357-82. Unique Identifier : AIDSLINE MED/83306040
Reichert CM; O'Leary TJ; Levens DL; Simrell CR; Macher AM
The acquired immune deficiency syndrome (AIDS) is a devastating new illness which appears to be sexually and parenterally transmissible. AIDS was first described in the male homosexual community; however, the disease has more recently been described among intravenous drug abusers, Haitians, hemophiliacs, and others. T
Letvin NL; Aldrich WR; King NW; Blake BJ; Daniel MD; Hunt RD
Acquired immuno-deficiency syndrome (AIDS) of macaques, an animal model for human AIDS, was transmitted to previously healthy macaque monkeys by means of inoculation of either tissue or a cell-free filtrate of a macaque lymphoma. The recipients showed evidence of profound lymphocyte dysfunction or died with infections
Evatt BL; Stein SF; Francis DP; Lawrence DN; McLane MF; McDougal JS; Lee TH; Spira TJ; Cabradilla C; Mullens JI; Essex M
Human T cell leukaemia virus (HTLV), HTLV proviral DNA, and antibodies to HTLV or a related agent have recently been detected in patients with acquired immunodeficiency syndrome (AIDS). Antibodies against HTLV-related antigens were assayed by means of indirect living cell immunofluorescence of HTLV-infected cells in s
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