Specific translocations characterize Burkitt's-like lymphoma of homosexual men with the acquired immunodeficiency syndrome. NLM AIDSLINE Important note: Information in this article was accurate in 1983. The state of the art may have changed since the publication date.

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Specific translocations characterize Burkitt's-like lymphoma of homosexual men with the acquired immunodeficiency syndrome.

Blood. 1983 Jun;61(6):1265-8. Unique Identifier : AIDSLINE MED/83179287
Chaganti RS; Jhanwar SC; Koziner B; Arlin Z; Mertelsmann R; Clarkson BD

Abstract: A Burkitt's-like B-cell lymphoma (BLL) has recently been shown to be associated with the acquired immunodeficiency syndrome (AIDS), which affects homosexual men. We report cytogenetic studies of two BLL tumors in homosexual men. Both tumors had chromosome translocations characteristic of Burkitt's lymphoma (BL), one the t(8;14) and the other the t(8;22). The pathway of lymphomagenesis in this disorder is discussed in the light of recent data on chromosome change and localization of immunoglobulin genes and oncogenes.
Keywords: Acquired Immunodeficiency Syndrome/COMPLICATIONS/*GENETICS Adult Burkitt's Lymphoma/COMPLICATIONS/*GENETICS Case Report Chromosome Aberrations Chromosomes, Human, 21-22 Chromosomes, Human, 6-12 *Homosexuality Human Karyotyping Male Support, U.S. Gov't, P.H.S. *Translocation (Genetics) JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/complications/KWDgeneticsadultburkitt'slymphoma/complications/KWDgeneticscasereportchromosomeaberrationschromosomes,human,21-22chromosomes,human,6-12KWDhomosexualityhumankaryotypingmalesupport,uKWDsKWDgov't,pKWDhKWDs
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M8380040

Copyright © 1983 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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