Important note: Information in this article was accurate in 1983. The state of the art may have changed since the publication date.
Human cryptosporidiosis in immunocompetent and immunodeficient persons. Studies of an outbreak and experimental transmission.
N Engl J Med. 1983 May 26;308(21):1252-7. Unique Identifier : AIDSLINE MED/83192324 Current WL; Reese NC; Ernst JV; Bailey WS; Heyman MB; Weinstein WM
Abstract:
Infection with cryptosporidium occurred in 12 immunocompetent persons who had direct contact with the feces of infected calves during three unrelated outbreaks of calf cryptosporidiosis. Nine of the twelve subjects had diarrhea and abdominal cramps that lasted 1 to 10 days. Infections were diagnosed and monitored by detection of oocysts in feces, with a modified Sheather's flotation technique and phase-contrast microscopy. Oocysts of cryptosporidium were isolated from calves but not from other animals with which these subjects had been in contact. Oocysts of cryptosporidium were also detected during repeated examinations of feces from two immunodeficient patients with persistent cryptosporidiosis. An apparently identical infection was transmitted to calves and mice, using oocysts from infected calves and human beings. Oocysts from an immunodeficient person also produced infections in kittens, puppies, and goats. This study shows that cryptosporidium may produce a moderate self-limited illness in immunocompetent persons, which contrasts sharply with the prolonged severe diarrhea in immunocompromised patients who contract cryptosporidiosis. Calves with diarrhea should be considered a potential source of human infection, and immunocompromised persons should avoid contact with such animals.
Keywords: Acquired Immunodeficiency Syndrome/COMPLICATIONS Adolescence Adult Agammaglobulinemia/COMPLICATIONS Animal Case Report Cats Cattle Cattle Diseases/TRANSMISSION Coccidia/ISOLATION & PURIF Coccidiosis/DIAGNOSIS/*TRANSMISSION/VETERINARY Disease Outbreaks/EPIDEMIOLOGY Dogs Female Goats Human Immune Tolerance Immunologic Deficiency Syndromes/*COMPLICATIONS Male Mice Middle Age Support, Non-U.S. Gov't Support, U.S. Gov't, Non-P.H.S. Zoonoses JOURNAL ARTICLE
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Important note: Information in this article was accurate in 1983. The state of the art may have changed since the publication date.
