Proviral DNA of a retrovirus, human T-cell leukemia virus, in two patients with AIDS. NLM AIDSLINE Important note: Information in this article was accurate in 1983. The state of the art may have changed since the publication date.

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Proviral DNA of a retrovirus, human T-cell leukemia virus, in two patients with AIDS.

Science. 1983 May 20;220(4599):862-5. Unique Identifier : AIDSLINE MED/83197366
Gelmann EP; Popovic M; Blayney D; Masur H; Sidhu G; Stahl RE; Gallo RC

Abstract: The acquired immune deficiency syndrome (AIDS) is characterized by T-lymphocyte dysfunction and is frequently accompanied by opportunistic infections and Kaposi's sarcoma. Human T-cell leukemia virus (HTLV) is associated with T-cell malignancies and can transform T lymphocytes in vitro. In an attempt to find evidence of HTLV infection in patients with AIDS, DNA from samples of peripheral blood lymphocytes from 33 AIDS patients was analyzed by Southern blot-hybridization with a radiolabeled cloned HTLV DNA probe. Analysis of DNA from both the fresh (uncultured) lymphocytes and from T cells cultured with T-cell growth factor revealed the presence of integrated HTLV proviral sequences in lymphocytes from two of the patients, both of whom had antibody to HTLV. The proviral sequences could not be detected in blood samples obtained from these individuals at a later date, consistent with the possibility that the population of infected cells had become depleted.
Keywords: Acquired Immunodeficiency Syndrome/ETIOLOGY/IMMUNOLOGY/ *MICROBIOLOGY Adult Animal Cats DNA, Viral/*ANALYSIS Human Male Middle Age *Retroviridae/GENETICS T-Lymphocytes/ANALYSIS/MICROBIOLOGY Tumor Virus Infections/COMPLICATIONS/*MICROBIOLOGY JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/etiology/immunology/KWDmicrobiologyadultanimalcatsdna,viral/KWDanalysishumanmalemiddleageKWDretroviridae/geneticst-lymphocytes/analysis/microbiologytumorvirusinfections/complications/KWDmicrobiologyjournalarticle
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Copyright © 1983 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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