Isolation of human T-cell leukemia virus in acquired immune deficiency syndrome (AIDS). NLM AIDSLINE Important note: Information in this article was accurate in 1983. The state of the art may have changed since the publication date.

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Isolation of human T-cell leukemia virus in acquired immune deficiency syndrome (AIDS).

Science. 1983 May 20;220(4599):865-7. Unique Identifier : AIDSLINE MED/83197367
Gallo RC; Sarin PS; Gelmann EP; Robert-Guroff M; Richardson E; Kalyanaraman VS; Mann D; Sidhu GD; Stahl RE; Zolla-Pazner S; Leibowitch J; Popovic M

Abstract: Several isolates of a human type-C retrovirus belonging to one group, known as human T-cell leukemia virus (HTLV), have previously been obtained from patients with adult T-cell leukemia or lymphoma. The T-cell tropism of HTLV and its prevalence in the Caribbean basin prompted a search for it in patients with the epidemic T-cell immune deficiency disorder known as AIDS. Peripheral blood lymphocytes from one patient in the United States and two in France were cultured with T-cell growth factor (TCGF) an shown to express HTLV antigens. Virus from the U.S. patient was isolated and characterized and shown to be related to HTLV subgroup I. The virus was also transmitted into normal human T cells from umbilical cord blood of a newborn. Whether or not HTLV-I or other retroviruses of this family with T-cell tropism cause AIDS, it is possible that patients from whom the virus can be isolated can also transmit it to others. If the target cell of AIDS is the mature T cell as suspected, the methods used in these studies may prove useful for the long-term growth of these cells and for the identification of antigens specific for the etiological agent of AIDS.
Keywords: Acquired Immunodeficiency Syndrome/ETIOLOGY/IMMUNOLOGY/ *MICROBIOLOGY Animal Antibodies, Monoclonal/IMMUNOLOGY Antibodies, Viral/IMMUNOLOGY Female Human Immunity, Cellular Male Retroviridae/*ISOLATION & PURIF Support, U.S. Gov't, Non-P.H.S. T-Lymphocytes/MICROBIOLOGY Tumor Virus Infections/COMPLICATIONS/*MICROBIOLOGY/TRANSMISSION JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/etiology/immunology/KWDmicrobiologyanimalantibodies,monoclonal/immunologyantibodies,viral/immunologyfemalehumanimmunity,cellularmaleretroviridae/KWDisolation&purifsupport,uKWDsKWDgov't,non-pKWDhKWDsKWDt-lymphocytes/microbiologytumorvirusinfections/complications/KWDmicrobiology/transmissionjournalarticle
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Copyright © 1983 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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