Acquired immunodeficiency syndrome in a colony of macaque monkeys. NLM AIDSLINE Important note: Information in this article was accurate in 1983. The state of the art may have changed since the publication date.

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Acquired immunodeficiency syndrome in a colony of macaque monkeys.

Proc Natl Acad Sci U S A. 1983 May;80(9):2718-22. Unique Identifier : AIDSLINE MED/83195124
Letvin NL; Eaton KA; Aldrich WR; Sehgal PK; Blake BJ; Schlossman SF; King NW; Hunt RD

Abstract: A naturally occurring immunodeficiency syndrome has been seen in a captive colony of macaque monkeys. This syndrome is seen primarily in the species Macaca cyclopis. Affected animals died with lymphomas (a rare disease in macaques) or such opportunistic infections as Pneumocystis carinii and noma (necrotizing gingivitis). These M. cyclopis exhibited anemia, neutropenia, and a circulating bizarre immature monocyte. In addition, liver function tests suggested hepatitis. Pokeweed mitogen-, concanavalin A-, and xenogeneic cell-stimulated proliferative responses by lymphocytes of animals with the syndrome were dramatically diminished. The T4 (helper, inducer)/T8 (suppressor, cytotoxic) ratio in the peripheral blood mononuclear T-cell populations of M. cyclopis in this colony are decreased when compared with those from either Macaca mulatta in the same colony or normal humans. Epidemiologic evidence implicates a common source agent in this syndrome. The similarity of this syndrome in macaques to human acquired immunodeficiency syndrome suggests that it may provide an important model for studying the human syndrome.
Keywords: Acquired Immunodeficiency Syndrome/*PHYSIOPATHOLOGY Animal *Disease Models, Animal Female Fluorescent Antibody Technique Immune Tolerance Leukocyte Count Macaca Male Species Specificity Support, U.S. Gov't, P.H.S. T-Lymphocytes/IMMUNOLOGY T-Lymphocytes, Helper-Inducer/ANALYSIS T-Lymphocytes, Suppressor-Effector/ANALYSIS JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDphysiopathologyanimalKWDdiseasemodels,animalfemalefluorescentantibodytechniqueimmunetoleranceleukocytecountmacacamalespeciesspecificitysupport,uKWDsKWDgov't,pKWDhKWDsKWDt-lymphocytes/immunologyt-lymphocytes,helper-inducer/analysist-lymphocytes,suppressor-effector/analysisjournalarticle
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M8380013

Copyright © 1983 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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