Tubulo-interstitial nephritis associated with polyomavirus (BK type) infection. NLM AIDSLINE Important note: Information in this article was accurate in 1983. The state of the art may have changed since the publication date.

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Tubulo-interstitial nephritis associated with polyomavirus (BK type) infection.

N Engl J Med. 1983 May 19;308(20):1192-6. Unique Identifier : AIDSLINE MED/83192305
Rosen S; Harmon W; Krensky AM; Edelson PJ; Padgett BL; Grinnell BW; Rubino MJ; Walker DL

Abstract: We studied viral injury to the kidney in a six-year-old boy with hyperimmunoglobulin M immunodeficiency who presented with irreversible acute renal failure and eventually died after five months of dialysis. Renal biopsy at the time of his presentation revealed a predominantly tubulo-interstitial process with numerous viral inclusions that were identified as polyomavirus. Urine cultures showed a massive viruria with BK-type, polyomavirus. The kidney disease was end stage, with persistence of BK virus identified by morphologic techniques and by culture. DNA hybridization analysis showed virus in low concentration in the lymph nodes, spleen, and lungs. The marked viruria, the high concentration of BK virus, and the extensive distribution of viral antigen throughout the kidney all suggest that infection with BK virus was the basis of the severe renal parenchymal injury.
Keywords: Animal Case Report Child Dysgammaglobulinemia/CONGENITAL DNA Human Hypergammaglobulinemia/COMPLICATIONS IgM Immunologic Deficiency Syndromes/COMPLICATIONS Kidney/MICROBIOLOGY Kidney Failure, Chronic/ETIOLOGY Male Nephritis, Interstitial/*ETIOLOGY/MICROBIOLOGY Nucleic Acid Hybridization Polyomavirus/IMMUNOLOGY/ISOLATION & PURIF Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. Tumor Virus Infections/*COMPLICATIONS Urine/MICROBIOLOGY JOURNAL ARTICLE

KWDanimalcasereportchilddysgammaglobulinemia/congenitaldnahumanhypergammaglobulinemia/complicationsigmimmunologicdeficiencysyndromes/complicationskidney/microbiologykidneyfailure,chronic/etiologymalenephritis,interstitial/KWDetiology/microbiologynucleicacidhybridizationpolyomavirus/immunology/isolation&purifsupport,non-uKWDsKWDgov'tsupport,uKWDsKWDgov't,pKWDhKWDsKWDtumorvirusinfections/KWDcomplicationsurine/microbiologyjournalarticle
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Copyright © 1983 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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